中山醫學大學機構典藏 CSMUIR:Item 310902500/10488
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    题名: Relationship between serum and urine interleukin-6 elevations and renal scarring in children with acute pyelonephritis.
    作者: Sheu JN
    Chen MC
    Chen SM
    Chen SL
    Chiou SY
    Lue KH
    贡献者: 中山醫學大學
    关键词: Acute pyelonephritis;children;interleukin-6;renal scarring;99mTc-dimercaptosuccinic acid scan
    日期: 2009
    上传时间: 2015-03-18T03:56:31Z (UTC)
    ISSN: 0036-5599
    摘要: OBJECTIVE:
    Acute pyelonephritis is a common infectious disease in children and can result in permanent renal damage. Interleukin-6 (IL-6) is an important mediator of inflammation in response to bacterial infection. This study investigated the potential relationship between acute-phase IL-6 and subsequent renal scarring in children with a first time febrile acute pyelonephritis.
    MATERIAL AND METHODS:
    In total, 79 children (age range 1-120 months) with a first time febrile urinary tract infection (UTI) were included. The diagnosis of acute pyelonephritis was confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) renal scan. Serum and urine samples were collected for IL-6 measurement by enzyme-linked immunosorbent assay before antibiotic treatment for the infection.
    RESULTS:
    The 79 children were divided into acute pyelonephritis (n=45) and lower UTI (n=34) groups according to the findings of DMSA scans. The initial serum and urine IL-6 levels of children with acute pyelonephritis were significantly higher compared with lower UTI (p < 0.001). Renal scarring was detected at the follow-up DMSA scans in 15 (34.1%) of the 44 children with acute pyelonephritis. Both serum and urine IL-6 levels during the acute phase of pyelonephritis were significantly higher in children with renal scarring than in those without (p=0.005 and p = 0.002). The median age of children with renal scarring was significantly lower than those without (p=0.034). Multiple regression analysis showed that higher initial serum and urine IL-6 levels and a younger age were associated with renal scarring.
    CONCLUSION:
    These results demonstrate that in younger children with a first time febrile acute pyelonephritis, elevations of the acute-phase serum and urine IL-6 levels were correlated with an increased risk of subsequent renal scarring.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10488
    http://dx.doi.org/10.1080/00365590802478742
    關聯: Scand J Urol Nephrol. 2009;43(2):133-7.
    显示于类别:[醫學系] 期刊論文

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