過去至今，深部腦刺激手術（deep brain stimulation, DBS）治療巴金森氏症（Parkinson’s disease, PD），是以有框架( Frame-based)式立體定位手術方式進行。但是，最近無框架( Frameless) 式立體定位手術已經成熟，這避免病患因被固定頭部的框架，造成患者發生不適。本論文針對DBS手術進行的研究，比較有框架式和無框架手術PD的患者。12病患接受DBS手術，從這些患者中，6位進行了有框架式DBS手術的和6位使用無框架式DBS手術，評估6個月後手術的效果、手術時間的長度、視丘下核( Subthalamic Necleus, STN)電極接觸長度、微電極記錄（Micro-electro Recording, MER）和術前術後巴金森氏症評分量表( Unify Parkinson’s Disease Rating Scale, UPDRS)評分進行比較。這個研究發現無框架和有框架之間手術效果相同，並得出結論認為無框架手術方式可以成為替代方案。 Historically deep brain stimulation (DBS) for Parkinson ’s disease(PD) has been performed by frame-based stereotaxy. However, recently the option of frameless stereotaxy has become available. This avoids the potential discomfort the patient may experience because of the frame fixed to the head. This study compared clinical outcomes of DBS performed using frame-based and frameless procedures for PD patients. Twelve patients underwent DBS operations; from these patients, six underwent frame-based and six underwent frameless DBS operations, and assessed 6 months later. Operation time, subthalamic electrode contact length, microelectrode recording (MER) tracts, and unified PD rating scale scores were evaluated and the scores were compared. This small study found no differences between frameless or frame based DBS, and concludes that framless system maybe an acceptable alternative.
