Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model

doi:10.1016/j.jmii.2014.08.001

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/9789

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题名:	Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model
作者:	Wu, Chia-Ta Chen, Peng-Jung Lee, Yu-Tzu Ko, Jiunn-Liang Lue, Ko-Haung
贡献者:	醫學研究所
关键词:	airway hyper-responsiveness asthma Lactobacillus rhamnosus GG probiotics
日期:	2014-08-07
上传时间:	2014-12-01T08:53:53Z (UTC)
出版者:	In Press
ISSN:	1684-1182
摘要:	Background Asthma is a common allergic disease. In previous studies, probiotics improved the balance of intestinal microbes, reduced inflammation, and promoted mucosal tolerance. This study investigated whether oral administrations of Lactobacillus rhamnosus GG (LGG) inhibited allergen (ovalbumin or OVA)-induced airway inflammation in a mouse asthma model. Methods The allergy/asthma animal model in this study was sensitization with OVA. After intranasal challenge with OVA, the airway inflammation and hyper-responsiveness were determined by a Buxco system, bronchoalveolar lavage fluid analysis with Liu stain, and enzyme-linked immunosorbent assay. Histopathologic changes in the lung were detected by hematoxylin and eosin staining and immunohistochemistry staining. Results Both pre- and post-treatment with LGG suppressed the airway hyper-responsiveness to methacholine and significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid and serum compared with the OVA-sensitized mice. In addition, LGG reduced OVA-specific IgE levels in serum. Oral LGG decreased matrix metalloproteinase 9 expression in lung tissue and inhibited inflammatory cell infiltration. Conclusion LGG had an anti-inflammatory effect on OVA-induced airway inflammation and might be an additional or supplementary therapy for allergic airway diseases.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/9789 http://dx.doi.org/10.1016/j.jmii.2014.08.001
關聯:	J Microbiol Immunol Infect. 29, 1567-1574.
显示于类别:	[醫學系] 期刊論文

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