血漿中MCP-1濃度與缺血性中風嚴重程度之相關性探討

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Title:	血漿中MCP-1濃度與缺血性中風嚴重程度之相關性探討 Study of the plasma Monocyte Chemoattractant Ptotein-1 levels in association with the severity in Ischemic Stroke patients
Authors:	王瑜婷 Wang, Yu-Ting
Contributors:	中山醫學大學：生化暨生物科技研究所;鄭鈞文
Keywords:	單核球細胞趨化蛋白-1;缺血性中風 Monocyte Chemoattractant Ptotein-1;Ischemic Stroke
Date:	2013
Issue Date:	2014-01-15T04:44:34Z (UTC)
Abstract:	缺血性中風的發生為大腦供血的血管內阻塞的結果。引起缺血性中風的兩個原因為腦血栓及腦栓塞，若可以預測中風的發生，減少中風的發生和降低中風的嚴重程度，亦可減少醫療資源和家庭經濟的負擔。發炎細胞的趨化移動和動脈粥狀硬化相關的疾病有：缺血性中風和心肌梗塞。目前已經證實在腦缺血發生之前在病灶的地方會有許多的細胞因子和趨化因子表現增加，趨化因子單核細胞趨化蛋白-1（MCP-1）吸引白血球細胞到局部缺血的組織，造成腦部的損傷。而具有動脈粥樣硬化斑塊的人為缺血性中風的高風險者。從以往的研究已證實MCP-1和缺血性中風的發病率有相關。本篇研究想要探討單核球趨化蛋白-1(MCP-1)和缺血性中風的嚴重程度之相關性。本研究收集了335個血液檢體，220位是中風發病者，115位是對照組並沒有任何嚴重病史，使用ELIASA方式分析血漿中MCP-1濃度。並收集受測者的臨床相關數據並有風險因素分析詳細調查，來作為危險因素分析。結果發現，對照組的血漿中MCP-1的濃度0.41±0.19 ng/ml，中風發病組的血漿中MCP-1的濃度0.43±0.20 ng/ml，中風發病組高於對照組具有相關性(P=0.04)。接著分析病人血漿中MCP-1濃度與中風嚴重程度無相關性。若依性別進行分析，發現中風發病組的男性血漿中MCP-1濃度高於對照組，具有顯著的相關性(P=0.002)。同樣的，MCP-1和危險因素(高血壓、糖尿病…等)，分析結果顯示高血壓、抽菸、喝酒具有相關性，其和年齡亦無相關性。結論：缺血性中風的發生和血漿中的MCP-1濃度有相關，但無法證實MCP-1和缺血性中風的嚴重程度具有相關性。 Ischemic strokes occur as a result of an obstruction within a blood vessel supplying blood to the brain. Two main causes for ischemic stroke are cerebral thrombosis and cerebral embolism. If can predict the occurrence of stroke, reduce the incidence of stroke and reduce the severity of stroke will also reduce medical resources and the burden on family. Chemokine-driven migration of inflammatory cells has been implicated in pathogenesis of atherosclerosis-associated conditions such as ischemic stroke and myocardial infarction. It is well established that cerebral ischemia results in increased expression of several cytokines and chemokines that precedes infiltration of leukocytes into the ischemic lesion. These leukocytes contribute to tissue injury in ischemic stroke. Individuals with symptomatic carotid atherosclerotic plaque have high risk of ischemic stroke. Previous studies have shown an association between MCP-1 levels and the incidence of ischemic stroke. In the study, investigate plasma MCP-1 levels and the severity ischemic stroke , we speculate that the increase in MCP-1 may increase the severity of ischemic stroke.There, venous blood from 335 human subjects was collected, 220 blood samples of which were obtained from patients with stroke, and 115 healthy controls who had no history of serious illness. Plasma MCP-1 levels were measured using enzyme-linked immunosorbent assay. We also correlated the data clinically and carried out risk factor analysis based on the detailed questionnaire obtained from each patient. In comparison to control subject (control mean:0.41±0.19ng/ml), MCP-1 plasma levels were increased in stroke patient (stroke mean: 0.43±0.20ng/ml), have higher correlated was between control and stroke(P=0.04). That form severity analysis, it was ovserved not association with severity in patients. That form gender analysis, with significant correlation (P =0.02), case male than control men. Similarly, no relationship was ovserved between chemokine levels stroke risk factors(hypertension, diabetesetc), Analysis showed that hypertension , smoking, and alcohol consumption correlated and MCP-1 was also not related to gender. Conclusion: The incidence of ischemic stroke and plasma MCP-1 concentrations are related, but could not confirm MCP-1 and ischemic stroke the severity of correlated.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/9024
Appears in Collections:	[The Institute of Biochemistry, Microbiology and Immunology ] Electronic Theses of Dissertation

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