Gellan Gum Films for Effective Guided Bone Regeneration

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/4483

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/4483

Title:	Gellan Gum Films for Effective Guided Bone Regeneration
Authors:	Chang, Shwu-Jen Kuo, Shyh-Ming Liu, Wei-Ting Niu, Cheng-Chie Gregory Lee, Ming-Wei Wu, Chun-Shien
Contributors:	中山醫學大學醫學檢驗暨生物技術學系
Keywords:	Guided bone regeneration GBR Film Gellan gum
Date:	2010-04-01
Issue Date:	2012-08-20T08:19:53Z (UTC)
Abstract:	Guided bone regeneration (GBR) films with bioabsorbable characteristics have been employed for surgical procedures to prevent the growth of scar tissue in the bone graft site. GBR films provide an isolated space over regions with defective tissues and prevent the invasion of fibrous connective tissue into the defect space, and can thus promote bone healing. In this study, we employed Gellan gum (GG) as viable film material and evaluated its potential for GBR applications. Three types of GG films (1%, 1.5%, 2%) were prepared. The tensile strength increased with an increase of film thickness. The 2% and 1.5% GG films were 2.87 and 1.96 times, respectively, the tensile strength of the 1% GG film. However, 1%, 1.5% and 2% GG films were degraded in strength by about 60%, 50% and 20% of initial value, respectively, after 30-day shaking test. Consequently, standardized, transosseous, and critical-sized (cavity of 6mm) skull defects were made in Sprague-Dawley (SD) rats, and the defective regions were covered with the 2% GG film. After 2 months of recovering, the GG film covered regions showed a clear boundary space between connective tissue and evidenced collagen would not grow into the space of the bone defect. It is concluded that the 2% GG film has great promise for application in GBR in general.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4483
Relation:	Journal of Medical and Biological Engineering 30卷2期(2010/04/01) 99 -103
Appears in Collections:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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