Epigallocatechin-3 Gallate Inhibits Invasion, Epithelial−Mesenchymal Transition, and Tumor Growth in Oral Cancer Cells

doi:10.1021/jf1049408

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/4473

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题名:	Epigallocatechin-3 Gallate Inhibits Invasion, Epithelial−Mesenchymal Transition, and Tumor Growth in Oral Cancer Cells
作者:	Chen, Pei-Ni Chu, Shu-Chen Kuo, Wu-Hsien Chou, Ming-Yung Lin, Jen-Kun Hsieh, Yih-Shou
贡献者:	中山醫學大學生化暨生物科技研究所
关键词:	EMT u-PA MMP invasion EGCG
日期:	2011-03-09
上传时间:	2012-08-16T07:49:01Z (UTC)
ISSN:	0021-8561
摘要:	Epithelial to mesenchymal transition (EMT) is critical for the progression, invasion, and metastasis of epithelial tumorgenesis. Here, we provided molecular evidence associated with the antimetastatic effect of green tea polyphenol epigallocatechin-3 gallate (EGCG) in an oral squamous cell culture system by showing a nearly complete inhibition on the invasion (P < 0.001) of squamous cell carcinoma-9 (SCC-9) cells via a reduced expression of matrix metalloproteinase-2 (P < 0.001) and urokinasetype plasminogen activator (P < 0.001). EGCG exerted an inhibitory effect on cell migration (P < 0.001), motility (P < 0.001), spread, and adhesion (P < 0.001). We performed Western blot to find that EGCG inhibited p-focal adhesion kinase (p-FAK), p-Src, snail-1, and vimentin, indicating the anti-EMT effect of EGCG in oral squamous cell carcinoma. EGCG was also sufficient to inhibit phorbol-12-myristate-13-acetate-induced cell invasion and matrix metalloproteinase-9 expression, as evidenced by its inhibition on the tumor growth of SCC-9 cells in vivo via cancer cell xenografted nude mice mode. These results suggested that EGCG could reduce the invasion and cell growth of tumor cells, and such a characteristic may be of great value in developing a potential cancer therapy.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4473 http://dx.doi.org/10.1021/jf1049408
關聯:	J. Agric. Food Chem 2011, 59 (8), pp 3836–3844
显示于类别:	[生化微生物免疫研究所] 期刊論文

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