Effects of d-cycloserine on MPTP-induced behavioral and neurological changes: Potential for treatment of Parkinson's disease dementia

doi:10.1016/j.bbr.2011.01.028

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 心理學系暨臨床心理學暨碩士班 > 期刊論文 > Item 310902500/4385

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题名:	Effects of d-cycloserine on MPTP-induced behavioral and neurological changes: Potential for treatment of Parkinson's disease dementia
作者:	Ho, Ying-Jui Hoa, Shih-Chun Pawlak, Cornelius Rainer Yeh, Kuei-Ying
贡献者:	中山醫學大學心理學系
关键词:	Parkinson's disease NMDA receptor d-Cycloserine Dementia Neuroinflammation Cognition
日期:	2011-01-16
上传时间:	2012-07-31T07:05:59Z (UTC)
ISSN:	1872-7549
摘要:	Glutamatergic dysfunction has been implicated in the neurodegeneration seen in Parkinson's disease (PD). Sub-chronic intraperitoneal injection with d-cycloserine (DCS), a partial agonist at the glycine binding site of the N-methyl-d-aspartate (NMDA) receptor, at dosages of 30, 100, or 200 mg/kg/day, was used to evaluate the role of NMDA receptors in neuronal and behavioral changes in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD rat model. Starting one day after intra-nigral infusion of MPTP, transient disturbance of motor function in the rotarod test was observed. This impairment spontaneously recovered to control levels 6 days after MPTP lesioning and DCS treatment facilitated recovery. MPTP lesioning also caused deficits in working memory and anxiety-like behavior in the T-maze and elevated plus-maze tests, respectively. Further, object recognition was disrupted in MPTP-lesioned rats, and interleukin-2 levels in the striatum, amygdala, and non-prefrontal cortex were increased, both changes being restored by DCS treatment. Furthermore, MPTP lesion-induced dopaminergic degeneration, microglial activation, and cell loss in the hippocampal CA1 area were all improved by DCS treatment. These results suggest that NMDA receptors are involved in PD-related neuronal and behavioral dysfunctions and that DCS may have clinical potential in the treatment of dementia associated with PD.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4385 https://doi.org/10.1016/j.bbr.2011.01.028
關聯:	Behavioural Brain Research Volume 219, Issue 2, 1 June 2011, Pages 280–290
显示于类别:	[心理學系暨臨床心理學暨碩士班] 期刊論文

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