Role of the UL41 Protein of Pseudorabies Virus in Host Shutoff, Pathogenesis and Induction of TNF-α Expression

doi:10.1292/jvms.10-0059

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题名:	Role of the UL41 Protein of Pseudorabies Virus in Host Shutoff, Pathogenesis and Induction of TNF-α Expression
作者:	LIN, Hui-Wen HSU, Wei-Li CHANG, Yuan-Yen JAN, Ming-Shiou WONG, Min-Liang CHANG, Tien-Jye
贡献者:	中山醫學大學醫學系微免學科
关键词:	pseudorabies virus (PRV) tumor necrosis factor-α (TNF-α) UL41 virion host shutoff (vhs) protein
日期:	2010-04-10
上传时间:	2012-07-20T08:01:23Z (UTC)
ISSN:	0916-7250
摘要:	The vhs (virion host shutoff) is highly conserved in alphaherpesvirus, including pseudorabies virus (PRV). In an attempt to explore the function of vhs of PRV, we constructed and characterized a mutant virus (Δ41). In the absence of vhs activity, Δ41 mutant is highly attenuated in mice model and the lethality is correlated with the virus dissemination in neural tissues. As with herpes simplex virus type 1 (HSV-1), the prototype virus of alphaherpesvirus, the pronounced decrease in cellular protein synthesis triggered by wild type PRV was largely restored in cells infected with Δ41 virus. Furthermore, tumor necrosis factor-α (TNF-α) protein expression was elevated significantly in spleen of mice infected with vhs mutant virus. Since TNF-α has been indicated to be an important cytokine in the innate immune response against various infections, our results implicate vhs may contribute to the protection against PRV lethality via the action of TNF-α. Overall, we confirm the shutoff function of vhs protein in PRV, and demonstrate the role that vhs protein plays in virulence, and regulation of cytokine production.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4341 http://dx.doi.org/10.1292/jvms.10-0059
關聯:	Journal of Veterinary Medical Science Vol. 72 (2010) , No. 9 p.1179).
显示于类别:	[醫學應用微生物研究所] 期刊論文

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