Taurine alleviates dyslipidemia and liver damage induced by a high-fat/cholesterol-dietary habit

doi:10.1016/j.foodchem.2009.10.001

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题名:	Taurine alleviates dyslipidemia and liver damage induced by a high-fat/cholesterol-dietary habit
作者:	Yang, Shun-Fa Tzang, Bor-Show Yang, Kuo-Tai Hsiao, Yuan-Chao Chang, Yuan-Yen Chan, Chi-Ho Fu, Shih-Guei Chen, Yi-Chen
贡献者:	中山醫學大學醫學系微免學科
关键词:	Taurine Serum lipids Hepatic lipids Faecal lipids and bile acid HMG-CoA reductase CYP7A1 LDL receptor GPT GOT Hepatic C-reactive protein
日期:	2009-10-05
上传时间:	2012-07-20T07:19:50Z (UTC)
ISSN:	0308-8146
摘要:	Eight male hamsters per group were assigned randomly to one of the following diets: chow diet (Control); high-fat/cholesterol diet (HFCD); HFCD supplemented with 1% Tau (HFCD/1% Tau); HFCD supplemented with 2% Tau (HFCD/2% Tau). Tau supplementation improved (P < 0.05) serum lipids and cholesterol profile in the high-fat/cholesterol-dietary hamsters. Although hepatic cholesterol/triacylglycerol in the high-fat/cholesterol-dietary hamsters were not (P > 0.05) changed by Tau supplementation, faecal cholesterol and bile acid outputs were increased (P < 0.05). Two percent Tau supplementation unregulated (P < 0.05) HMG-CoA reductase and cholesterol 7-α hydroxylase (CYP7A1) expressions in the high-fat/cholesterol-dietary hamsters. Besides, Tau supplementation also increased (P < 0.05) LDL receptor mRNA expressions in high-fat/cholesterol-dietary hamsters. Tau supplementation also reduced serum GPT and GOT values and C-reactive protein (CRP) levels in the high-fat/cholesterol-dietary hamsters. Results clearly indicated that Tau could alleviate blood lipids and hepatic damage induced by a high-fat/cholesterol-dietary diet.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4338 http://dx.doi.org/10.1016/j.foodchem.2009.10.001
關聯:	Food Chemistry Volume 120, Issue 1, 1 May 2010, Pages 156–162
显示于类别:	[醫學應用微生物研究所] 期刊論文

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