中山醫學大學機構典藏 CSMUIR:Item 310902500/4330
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    题名: In vitro physiochemical properties of a biomimetic gelatin/chitosan oligosaccharide/calcium silicate cement
    作者: Chun-Cheng Chen
    Wei-Chung Wang
    Shinn-Jyh Ding
    贡献者: 中山醫學大學口腔醫學院
    牙醫學系
    http://dx.doi.org/10.1002/jbm.b.31737
    关键词: calcium silicate
    activity
    degradation
    chitosan
    gelatin
    日期: 2010-09-28
    上传时间: 2012-07-19T07:48:49Z (UTC)
    ISSN: 1552-4973
    摘要: Calcium silicate cement (CSC) has favorable biocompatible properties that may support its clinical use as bone defect repair. A hybrid cement was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT)-containing calcium silicate powder in a solid phase. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. In this study, the in vitro physicochemical properties of CSC-GLT-COS hybrid cement were investigated. The results indicated that all cement specimens formed apatite spherulites in simulated body fluid (SBF) for as little as 1 h. After immersion in a Tris-HCl solution, a pore structure appeared on all specimen surfaces without any precipitation. The presence of GLT did not adversely affect the physiochemical properties of CSC, even after 30 days of immersion. In contrast, COS could promote the degradation of CSC, as evidenced in the results of mechanical strength, weight loss, and ion concentration. The in vitro physiochemical properties of the hybrid cement makes it an attractive choice for dental and orthopedic applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/4330
    關聯: Journal of Biomedical Materials Research Part B: Applied Biomaterials
    Volume 95B, Issue 2, pages 456–465, November 2010
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