In vitro physiochemical properties of a biomimetic gelatin/chitosan oligosaccharide/calcium silicate cement

doi:10.1002/jbm.b.31737

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/4330

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/4330

Title:	In vitro physiochemical properties of a biomimetic gelatin/chitosan oligosaccharide/calcium silicate cement
Authors:	Chun-Cheng Chen Wei-Chung Wang Shinn-Jyh Ding
Contributors:	中山醫學大學口腔醫學院牙醫學系 http://dx.doi.org/10.1002/jbm.b.31737
Keywords:	calcium silicate activity degradation chitosan gelatin
Date:	2010-09-28
Issue Date:	2012-07-19T07:48:49Z (UTC)
ISSN:	1552-4973
Abstract:	Calcium silicate cement (CSC) has favorable biocompatible properties that may support its clinical use as bone defect repair. A hybrid cement was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT)-containing calcium silicate powder in a solid phase. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. In this study, the in vitro physicochemical properties of CSC-GLT-COS hybrid cement were investigated. The results indicated that all cement specimens formed apatite spherulites in simulated body fluid (SBF) for as little as 1 h. After immersion in a Tris-HCl solution, a pore structure appeared on all specimen surfaces without any precipitation. The presence of GLT did not adversely affect the physiochemical properties of CSC, even after 30 days of immersion. In contrast, COS could promote the degradation of CSC, as evidenced in the results of mechanical strength, weight loss, and ion concentration. The in vitro physiochemical properties of the hybrid cement makes it an attractive choice for dental and orthopedic applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4330
Relation:	Journal of Biomedical Materials Research Part B: Applied Biomaterials Volume 95B, Issue 2, pages 456–465, November 2010
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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