Backgrounds: To investigate the association of stromal cell-derived factor-1
(SDF-1) gene polymorphisms with the neoplastic lesions of uterine cervix in
Mid-Taiwan women. Methods: 498 blood samples were collected from 161 patients
with neoplasia of uterine cervix, including 76 cancer patients and 61 patients with
high-grade dysplasia, 24 low-grade dysplasia, and 337 normal women. Stromal
cell-derived factor-1 (SDF-1) gene was selected. Results: Compared with
homozygotes GG, we found the heterozygote genotype, GA has no significantly
different distribution between patients with cervical neoplasia and normal women (P
= 0.539). Moreover, compared with cancer patients and patients with high-grade
dysplasia and low--grade dysplasia, women with GG also have no significantly
different distribution. Conclusions: SDF-1 A gene polymorphism could be not
considered as a factor related to an increased susceptibility of neoplasia of uterine
cervix.
