中山醫學大學機構典藏 CSMUIR:Item 310902500/3890
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    題名: Genetic polymorphism of CCR2-64I increased the susceptibility of hepatocellular carcinoma
    作者: Chao-Bin Yeh;Hsiu-Ting Tsai;Yi-Chen Chen;Wu-Hsien Kuo;Tzy-Yen Chen;Yi-Hsien Hsieh;Ming-Chih Chou;Shun-Fa Yang
    貢獻者: 中山醫學大學：醫學系
    關鍵詞: monocyte chemoattractant protein-1;chemokine receptor-2;hepatocellular carcinoma;polymorphism
    日期: 2010
    上傳時間: 2011-06-21T08:03:11Z (UTC)
    摘要: Background and Objectives
    The purpose of this study was to investigate genetic impact of monocyte chemoattractant protein-1 (MCP-1) and its receptor chemokine receptor-2 (CCR2) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC).
    Methods
    A total of 446 subjects, including 344 healthy controls and 102 patients with HCC, were recruited in this study and subjected to PCR-RFLP to estimate the impact of these two polymorphic variants on HCC.
    Results
    No relationship between MCP-1 ?2518G/A gene polymorphism and HCC risk was found among our recruited HCC patients and healthy controls. However, there was a significantly increased risk (AOR?=?1.91; 95% CI?=?1.11–3.29) of having HCC among subjects with GA heterozygotes of CCR2 V64I after adjusting for other confoundings. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions, as well as clinicopathological parameters of HCC for MCP-1 ?2518G/A and CCR2 V64I genes, respectively.
    Conclusions
    CCR2-64I gene polymorphism is an important factor for the susceptibility of HCC but it might not influence the clinical pathological progression of HCC, and the contribution of CCR2-64I gene polymorphism on the susceptibility of HCC could be not through the affection of liver injury-related clinical pathological characteristics.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/3890
    關聯: Journal of Surgical Oncology,Volume 102, Issue 3, pages 264–270, 1 September 2010
    顯示於類別:[醫學系] 期刊論文

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