中山醫學大學機構典藏 CSMUIR:Item 310902500/3782
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    题名: Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San
    作者: Lengsu William Chin;Yu-Wen Cheng;Shih-Shen Lin;Ya-Yun Lai;Long-Yau Lin;Ming-Yung Chou;Ming-Chih Chou;Chi-Chiang Yang
    贡献者: 中山醫學大學:應用化學系
    日期: 2010
    上传时间: 2011-05-17T08:49:16Z (UTC)
    ISSN: 0304-8608
    摘要: Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2–1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/3782
    http://dx.doi.org/10.1007/s00705-010-0779-9
    關聯: Archives of Virology,Volume 155, Number 12, 1933-1941;DOI: 10.1007/s00705-010-0779-9
    显示于类别:[醫學應用化學系暨碩士班] 期刊論文

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