Preparation, characterization and biological properties of Gellan gum films with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linker

doi:10.1016/j.carbpol.2010.06.019

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/3650

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/3650

题名:	Preparation, characterization and biological properties of Gellan gum films with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linker
作者:	Ming-Wei Lee;Hui-Ju Chen;Shu-Wei Tsao
贡献者:	中山醫學大學:醫學檢驗暨生物技術學系
关键词:	Gellan gum;EDC;Biocompatibility;Wound healing
日期:	2010
上传时间:	2011-03-22T08:44:59Z (UTC)
ISSN:	0144-8617
摘要:	Gellan gum (GG) is an exopolysaccharide produced by Sphingomonas elodea. To develop a medical application for GG, in this study we prepared 26 μm thick films of GG reacted with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) in 40% ethanol to obtain a cross-linked film (GG40) with 73% gel content and 52.4 MPa tensile strength. In vitro biocompatibility tests, GG40 film exhibit nontoxic effects for L929 cells and inhibit absorption and activation of platelets. When implanted into rat subcutaneous tissue, the GG40 film caused minor inflammation in the early postoperative period. The results indicate that the effects of GG40 film on wound healing, wound size reduction (%) and collagen content are higher than those found in commercial products (Duoderm). Therefore, we conclude that the GG film developed in this study has potential for future use in surgical applications.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3650 http://dx.doi.org/10.1016/j.carbpol.2010.06.019
關聯:	Carbohydrate Polymers,Volume 82, Issue 3, 15 October 2010, Pages 920-926
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html	期刊論文	0Kb	HTML	694	检视/开启

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....