Novel expression patterns of connexin 30.3 in adult rat cochlea

doi:10.1016/j.heares.2010.02.008

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 生物醫學科學學系暨碩士班 > 期刊論文 > Item 310902500/3634

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题名:	Novel expression patterns of connexin 30.3 in adult rat cochlea
作者:	Wang WH;Yang JJ;Lin YC;Yang JT;Li SY
贡献者:	中山醫學大學:生物醫學科學學系(所)
关键词:	Cx30.3;Immunohistochemistry;Laser capture microdissection;Cochlea
日期:	2010
上传时间:	2011-03-22T08:13:40Z (UTC)
ISSN:	0378-5955
摘要:	Mutations of the GJB4 gene; encoding connexin 30.3 (CX30.3); are associated with skin disorders. Recently; this gene was also detected in deaf individuals without skin disorders. However; the functional roles of CX30.3 in the cochlea remain unclear. A primary step toward understanding the role of CX30.3 in hearing and its dysfunction is the documentation of its cellular and sub-cellular locations within the cochlea. In the present study; we located and determined the cellular expression of Cx30.3 within the rat cochlea by using a polyclonal anti-Cx30.3 antibody. Expression of the Cx30.3 protein was detected in the spiral limbus; spiral ligament; spiral ganglion; and stria vascularis by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analyses. Our results indicate the presence and localization of Cx30.3 in the rat cochlea. Knowledge of the spatial distribution of Cx30.3 will provide important insights into its role in the cochleae and normal auditory function.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3634 http://dx.doi.org/10.1016/j.heares.2010.02.008
關聯:	Hearing Research. 265; 77-82.
显示于类别:	[生物醫學科學學系暨碩士班] 期刊論文

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