Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent

doi:10.1142/S0192415X09007594

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/3595

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题名:	Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent
作者:	Huang KS;Lu M;Chen Y;Tsai F;Kuo W;Cheng Y;Lin C;Tsai C;Huang C;Lin J;Ou H
贡献者:	中山醫學大學:醫學系
日期:	2009
上传时间:	2011-03-14T03:51:21Z (UTC)
ISSN:	0192-415X
摘要:	This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium (MTT), proliferating cell nuclear antigen (PCNA) Western blotting, and wound healing assays in Schwann cells administered with chishao (0-500 mg/ml), except at 500 mg/ml concentration. The chishao-treated cells also showed a dose-dependent activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA) and decreased plasminogen activator inhibitor-1 (PAI-1), enhanced proliferative proteins, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-signaling. Using mitogen-actvated protein kinase (MAPK)-signaling chemical inhibitors, U0126, SB203580, and SP600125, the proliferative effects of chishao on RSC cells were identified to be ERK- and JNK- signaling dependent. Based on the results, applying appropriate doses of chishao to Schwann cells would be a potential approach for enhancing neuron regeneration.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3595 http://dx.doi.org/10.1142/S0192415X09007594
關聯:	American Journal of Chinese Medicine (AM J CHINESE MED), 2009; 37(6): 1191-202 (28 ref)
显示于类别:	[醫學系] 期刊論文

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