Pyogenic liver abscess in the elderly: clinical features, outcomes, and prognostic factors

doi:10.1093/ageing/afp002

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/3591

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/3591

Title:	Pyogenic liver abscess in the elderly: clinical features, outcomes, and prognostic factors
Authors:	Shiuan-Chih Chen;Yuan-Ti Lee;Chi-Hua Yen;Kuang-Chi Lai;Long-Bin Jeng;Ding-Bang Lin;Po-Hui Wang;Chun-Chieh Chen1;Meng-Chih Lee;William R. Bell
Contributors:	中山醫學大學:醫學系
Keywords:	pyogenic liver abscess;elderly risk factor;prognosis
Date:	2009
Issue Date:	2011-03-14T03:51:16Z (UTC)
ISSN:	0002-0729
Abstract:	Background: pyogenic liver abscess (PLA) is a potentially life-threatening disease in middle-to-old aged persons. Objective: to compare the differences in clinical features and outcomes between older and younger PLA patients, and to identify predictors of outcomes in older patients. Design: retrospective chart review of all PLA patients between July 1999 and June 2007. Setting: a 1,600-bed primary and tertiary care centre. Subjects: in total, 339 patients were enrolled and included 118 ?65 years of age (the elderly group) and 221 patients <65 years of age (the non-elderly group). Methods: clinical features, laboratory, imaging and microbiologic findings, treatment and outcomes for each of the included patients were collected. The predictor of outcome was determined using logistic regression and purposeful selection of covariates. Results: the elderly group had a higher APACHE II score on admission, a biliary abnormality, a malignancy, a pleural effusion, polymicrobial, anaerobic or multi-drug-resistant isolates, inappropriate initial antibiotics, a longer hospitalisation and a longer parenteral antibiotic treatment period than the non-elderly group, whereas the non-elderly group was more likely to be alcoholic men with cryptogenic origin of abscess and Klebsiella pneumoniae infection. There was no difference in case fatality between the elderly (13.6%) and non-elderly (8.6%) groups despite the elderly group having a poorer host status on admission. In multivariate analysis, age (P = 0.028) and APACHE II score at admission ?15 (P = 0.001) were risk factors, but K. pneumoniae infection (P = 0.012) was a protective factor for fatality in older PLA patients. Conclusions: these data suggest that older PLA patients wound have a fair outcome compared to younger patients, but require longer hospitalisations.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3591 http://dx.doi.org/10.1093/ageing/afp002
Relation:	Age Ageing. 38(3), 271-276.
Appears in Collections:	[醫學系] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	380	View/Open

Loading...