中山醫學大學機構典藏 CSMUIR:Item 310902500/3571
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    题名: Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line
    作者: Te-jen LAI;Sheng-feng HSU;Te-mao LI;Horng-chaung HSU;Jaung-geng LIN;Chin-jung HSU;Ming-chih CHOU;Meng-chih LEE;Shun-fa YANG;Yi-chin FONG
    贡献者: 中山醫學大學:生命科學系
    关键词: alendronate;bisphosphonate;chondrosarcoma;matrix metalloproteinase;2;invasion;migration
    日期: 2007
    上传时间: 2011-03-14T03:50:47Z (UTC)
    ISSN: 1671-4083
    摘要: Aim: Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. The aim of the present study was to investigate the effect of alendronate, a bisphosphonate, on the invasion and migration of human chondrosarcoma cells (JJ012). Methods: JJ012 cells were treated with alendronate of various concentrations up to 100 μmol/L for a specified period, and then gelatin zymography and matrigel invasion assay was performed to study the effects of alendronate on matrix metalloproteinase (MMP)-2 activity and the invasion ability of JJ012 cells, respectively. Results: Our data showed that alendronate exerted a dose- and time-dependent inhibitory effect on the invasion and migration of JJ012 cells. Furthermore, gelatin zymography and RT-PCR showed that alendronate treatment decreased the activity and mRNA levels of MMP-2 in a concentration-dependent manner. Conclusion: Our findings suggest that alendronate may reduce MMP-2 secretion at the transcriptional and translational levels, and inhibit the invasion of chondrosarcoma cell. Therefore, alendronate may be a potential candidate for the systemic therapy of chondro-sarcomas, as well as other malignant diseases.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/3571
    http://dx.doi.org/10.1111/j.1745-7254.2007.00607.x
    關聯: Acta Pharmacol Sin. 2007 Aug;28(8):1231-5.
    显示于类别:[生物醫學科學學系暨碩士班] 期刊論文

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