Suppressive effects of wild bitter gourd (Momordica charantia Linn. var. abbreviata ser.) fruit extracts on inflammatory responses in RAW 264.7 macrophages

doi:10.1016/j.jep.2009.01.028

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题名:	Suppressive effects of wild bitter gourd (Momordica charantia Linn. var. abbreviata ser.) fruit extracts on inflammatory responses in RAW 264.7 macrophages
作者:	Chong-Kuei Liia;Haw-Wen Chena;Wen-Tzu Yun;Kai-Li Liu
贡献者:	中山醫學大學：營養學系
关键词:	Wild bitter gourd;Momordica charantia Linn. var. abbreviata ser.;Inducible nitric oxide synthase;Nitric oxide;NF-κB
日期:	2008
上传时间:	2011-03-01T02:30:13Z (UTC)
ISSN:	0378-8741
摘要:	Aim of the study Bitter gourd (Momordica charantia) is used to treat various diseases including inflammation. A wild species of bitter gourd, Momordica charantia Linn. var. abbreviata ser. (WBG), is considered to be more potent in disease prevention than is bitter gourd; however, little is known about the biological and physiological characteristics of WBG. Materials and methods The present study investigated the anti-inflammatory effect of WBG on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Results Among the hot water, 95% ethanol, and ethyl acetate extracts of WBG, the ethanol extract showed the greatest reduction of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production and inducible nitric oxide synthase (iNOS) and pro-interleukin-1β expression. LPS-induced cyclooxygenase-2 expression was not affected by WBG extracts. Compared with WBG, extracts from bitter gourd showed a lesser inhibition of LPS-induced events. Electrophoretic mobility shift assay further showed that both the hot water and the ethanol extracts of WBG inhibited NF-κB activation. Although information is lacking on the bioactive components of WBG, the phenolic compound contents of each extract significantly paralleled its anti-inflammatory ability (r = 0.74, 0.88 and 0.65 for NO, PGE2 and iNOS expression, respectively, P < 0.05). Conclusions These results suggest that WBG is beneficial for reducing LPS-induced inflammatory responses by modulating NF-κB activation.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3469 http://dx.doi.org/10.1016/j.jep.2009.01.028
關聯:	Journal of Ethnopharmacology.Volume 122, Issue 2, 18 March 2009, Pages 227-233
显示于类别:	[營養學系暨碩士班] 期刊論文

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