The aim of the present study was to evaluate whether the induction of multiple ovulation can increase the pregnancy rates in couples treated with AIH. 624 couples underwent a total of 1242 cycles of IUI with husband's sperm after ovarian stimulation with clomiphene citrate (CC)-human gonadotropin combination or human gonadotropins alone. We Compared the follicle numbers of induction by CC, CC/hMG, with the pregnancy rates, and the outcome of three stimulation protocols with washed husband's sperm of different parameter. This figure was significantly higher pregnancy rates in ovulation stimulation groups (15.6%) than natural group (8.3%). On the other hand, we also get satisfied results of oligospermia group (10.8%) and asthenospermia group (11.5%) after ovarian stimulation. However, there was still low pregnancy rates in the oligospermia groups (3.0%). It is therefore suggested that a trial of induction of multiple follicular development may be perfromed in couples with male-related before their inclusion in protocols for advance procedures, such in vitro fertilization (IVF) or intracytoplasmic sperm injection(ISCI).
