血液-中樞神經系統障壁(blood-central
nervous system barrier, blood-CNS
barrier)的限制(或選擇)，此屏障主要分
成血-腦屏障 (blood-brain barrier, BBB)
及血-腦脊髓液障壁
(blood-cerebrospinal fluid barrier,
blood-CSF barrier)兩個細胞性屏障
(cellular barrier)。BBB結構是由腦和脊
髓內毛細血管(capillary)之單層內皮細
胞(endothelial cells)緊密連接(tight
junction)組成，使大分子不能通過，但
水和某些離子仍能通過。Blood-CSF
barrier結構主要是脈絡叢(choroids plexus)之單層上皮細胞之間緊密連接。一些分解酵素參與腦障壁(brain
barrier)的破壞，其中包含基質金屬蛋
白酶(matrix metalloproteinases,
MMPs)，會分解細胞外質(extracellular
matrix, ECM)，增加BBB的通透性，媒
介腦部的發炎反應，引起神經發炎。
本研究顯示以廣東住血線蟲感染
BALB/c小白鼠，誘發嗜伊紅性腦膜炎
或嗜伊紅性腦膜腦炎(eosinophilic
meningoencephalitis)的模式，趨化因子
CCL-2 與細胞外質fibronectin分解有密
切關係。
Blood-central nervous system barrier
(blood-CNS barrier) consist of two
cellular barriers, blood-brain barrier
(BBB) and blood-cerebrospinal fluid
(blood-CSF) barrier is built up by a
monolayer of endothelial cells lining the
brain capillaries and restricting the blood
and the brain interstitial fluid. The
second barrier, blood-CSF barrier is
built up by a monolayer of epithelial
cells of the choroids plexus separating
the blood from the CSF. Some
proteolytic enzymes are involved in the
disruption of brain barriers. Matrix
metalloproteinase-9 (MMP-9) has been
identified an essential role in the
breakdown of the extracellular matrix (ECM) macromolecules、BBB
damage、as a mediator of brain
inflammatory reaction and induce
neuro-inflammatory diseases. Our study
showed that use the BALB/c mice
infected with Angiostrongylus
cantonensis induced-meningitis as a
model. We demonstrate the correlation
between chemokines CCL-2 and
fibronectin degradation.
Keywords：Angiostrongylus cantonensis;
meningitis; meningoencephalitis;
chemokines
