腦內PKA-CREB訊息傳遞路徑在安非它命重複刺激引發之厭食效應之角色

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 生理科 > 研究計劃 > Item 310902500/3064

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/3064

题名:	腦內PKA-CREB訊息傳遞路徑在安非它命重複刺激引發之厭食效應之角色 Role of Intracerebral PKA-CREB Signal Pathway in the Anorectic Effect of Repeated Adminstration of Amphetamine
作者:	郭東益 Kuo, Dong-Hih
贡献者:	中山醫學大學醫學系生理學科
关键词:	Amphetamine;NPY;PKA;CREB;Feeding behavior;Antisense oligonucleotide;Signaling transduction
日期:	2005
上传时间:	2010-12-06T03:33:50Z (UTC)
摘要:	Although amphetamine (AMPH)-induced appetite suppression has been attributed to its inhibitory action on neuropeptide Y (NPY), an appetite neurotransmitter abundant in the brain, molecular mechanisms underlying this effect are not well known. This manuscript examined the possible role of protein kinase A (PKA) and cAMP response element binding protein (CREB) signaling in this anorectic effect, and the results showed that both PKA and CREB mRNA levels in hypothalamus were increased following AMPH treatment, which were relevant to a reduction of NPY mRNA level. To determine if PKA or CREB was involved in the anorectic response, the intracerebroventricular infusions of antisense oligonucleotide (or missense control) were performed at 60 min before daily AMPH treatment in conscious rats, and results showed that either PKA or CREB knock down could block AMPH-induced anorexia as well as restore NPY mRNA level, indicating the respective involvement of PKA and CREB signaling in the regulation of NPY gene expression. It is suggested that hypothalamic PKA and CREB signaling may involve the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3064
显示于类别:	[生理科] 研究計劃

文件中的档案:

档案	描述	大小	格式	浏览次数
942320B040018.pdf	研究計畫成果報告	1234Kb	Adobe PDF	398	检视/开启

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....