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https://ir.csmu.edu.tw:8080/ir/handle/310902500/2941
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| Title: | 在肥胖症中內因性opioids作用在mu, delta, or kappa 接受體對心肺功能和運動的調節(I)
Preparation of NSC Project |
| Authors: | 李信達
Lee, Hsin-Ta |
| Contributors: | 中山醫學大學物理治療學系 |
| Keywords: | 換氣、血壓、心跳、心臟
Ventilation, blood pressure, Heart rate, Cardiac;Opioid |
| Date: | 2004 |
| Issue Date: | 2010-11-29T04:49:00Z (UTC)
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| Abstract: | 我們的主要目的是在調查在肥胖症中不正常心肺反應導因於不正常opioids作用在mu, delta, or kappa接受體的機制。24隻基因瘦鼠和24隻基因肥胖鼠被研究約12週大。換氣的反應用barometric和sphygmomanometric技術測試之前注射安慰劑或周圍opioid接受體阻斷劑naloxone methiodide(NM)or中央opioid接受體阻斷劑naloxone hydrochloride(NHCl), 或顱內微量注射opioid接受體阻斷劑如mu1接受體阻斷劑naloxonazine(NAL), mu-接受體阻斷劑CTOP, delta接受體阻斷劑naltrindole (NALT), 和kappa-接受體阻斷劑nor-Binaltorphimine (NB).
To determine whether altered central opioidergic (mu, delta, kappa) mechanisms contribute to the altered cardiopulmonary response in obese Zucker rats. 24 lean and 24 obese Zucker rats were studied. Ventilation (VE), tidal volume (VT), and breathing frequency (f), mean blood pressure (MBP), and heart rate (HR) were measured on separate occasions by the barometric and sphygmomanometric method following the randomized blinded administration of naloxone methiodide (NM, peripheral broad opioid antagonist), naloxone hydrochloride (NHCl, peripheral and central broad opioid antagonist), incracranial microinjections of naloxonazine (NAL, selective mu1 receptor antagonists), CTOP (mu-receptor antagonists), naltrindole (NALT, delta receptor antagonist), and nor-Binaltorphimine (NB, kappa-receptor antagonists). NM and NHCl in lean animals had no effect on ventilation and MBP, and HR. Similarly, NM failed to alter ventilation in obese rats. In contrast, NHCl significantly (P<0.05) increased VE and HR in obese rats. NAL did not affect VE, HR, BP in lean and obese rats and CTOP did not affect VE, HR, BP in lean rats whereas CTOP significantly increased VE, HR in obese rats. In lean and obese Zucker rats, VE, HR, and BP were unaffected by the administration of either NALT and NB. Cardiac TNFalpha in obese rats is higher than age-matched lean Zucker rats Thus, endogenous opioids modulate ventilation and heart rate in obese, but not lean, Zucker rats by acting specifically on mu (not on mu1, delta, kappa) receptors located within the central nervous system. |
| URI: | https://ir.csmu.edu.tw:8080/handle/310902500/2941 |
| Appears in Collections: | [物理治療學系暨碩士班] 研究計劃
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| 李信達.pdf | 國科會計劃報告書 | 131Kb | Adobe PDF | 756 | View/Open |
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