這項研究目的是想了解5種不同牙齒顏色複合樹脂基底修復材料的萃取液，對人類牙髓細胞的生物相容性。研究的設計：將5種不同牙齒顏色複合樹脂基底修復材料(2種添加樹脂的玻璃離子體修復材料；Fuji II LC和Fuji IX,1種Compomer；Dyract,和2種複合樹脂；Tetric和Superfil，聚合後放入細胞培養基液中2和5天，分別收集材料的萃取液，作用在人類牙髓細胞。評估複合樹脂基底修復材料對人類牙髓細胞的細胞毒性和線粒體活性分析。結果顯示複合樹脂基底修復材料的萃取液，對人類牙髓細胞俱有細胞毒性。另外，Superfil，FujiIX和Tetric顯示了對人類牙髓細胞的線粒體活性的抑制作用。同時被發現複合樹脂Superfil是毒性最強的修復材料。結論是細胞毒性的取決於材料成份種類。Compomer或FujiIILC添加樹脂的玻璃離子體修復材料，對人類牙髓細胞初期反應，較其它3種修復材料有較好細胞的生物相容性。
The objective of this study was to determine the cytocompatibility of 5 different extracts of resin-based restorative materials (2 resin-modified glass ionomer cements, 1 compomer, and 2 composite resins) on human pulp cells. Set specimens from 2 resin-modified glass-ionomer cements (Fuji II LC and Fuji IX), 1 compomer (Dyract), and 2 composite resins (Tetric and Superfil) were eluted with culture medium for 2 and 5 days. The effects of resin-based restorative materials on human pulp cells were evaluated with cytotoxicity and mitochondrial activity assays. The results showed that the eluates from resin-modified glass-ionomer, compomer, and composite resins were cytotoxic to primary human pulp cells. In addition, Superfil, Fuji IX, and Tetric demonstrated an inhibitory effect on mitochondrial activity of human pulp cells. It was found that composite resin Superfil was the most toxic restorative material among the chemicals tested. The influence of the cytotoxicity depended on the materials tested. Compomer or light-curing resin-modified glass ionomer may initially react more favorably to pulp cells.
