研究根管充填劑誘發發炎反應的機轉

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 研究計劃 > Item 310902500/2882

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题名:	研究根管充填劑誘發發炎反應的機轉 Study of the Induction of Inflammatory Mediators by Root Canal Sealers
作者:	黃富美;張育超 Huang, Fu-Mei;Chang, Yu-Chao
贡献者:	中山醫學院牙醫學系
关键词:	Root canal sealer;Inflammation;Interleukin-6;Interleukin-8
日期:	2004
上传时间:	2010-11-25T03:42:33Z (UTC)
摘要:	Histological investigations have demonstrated that root canal sealers can induce mild to severe inflammatory alternations. However, there is little information on the precise mechanisms about root canal sealers-induced inflammatory reaction. Dysregulated cytokine productions at local disease sites have been considered to be major contributors to the development of inflammatory diseases. Interleukin (IL)-6 and IL-8 released have been reported to play an important role in the pathogenesis of inflammation. The aim of this study was to investigate the effects of root canal sealers N2 (zinc-oxide eugenol based) and AH Plus (epoxy resin based) on the expression of IL-6 and IL-8 mRNA gene in human osteoblastic cell line U2OS cells. The levels of mRNAs were measured by the semi-quantitative reverse-transcriptase polymerase chain reaction analysis. The exposure of quiescent U2OS cells to N2 and AH Plus resulted in the induction of IL-6 and IL-8 mRNA gene expression (p . 0.05). The intensity of IL-8 mRNA gene was found to be significant higher than IL-6 mRNA gene (p . 0.05). Taken together, the activation of IL-6 and IL-8 mRNA gene expression may be one of the pathogenesis of zinc oxide-eugenol based and epoxy resin based root canal sealers-induced periapical inflammation.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/2882
显示于类别:	[牙醫學系暨碩士班] 研究計劃

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