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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/2769


    Title: 以不同成因的發炎性疾病（代謝症候群及僵直性脊椎炎） 探討維生素B-6 在發炎反應及脂質過氧化之角色: 病例-對 照及介入研究
    Authors: 黃怡嘉;黃建寧
    Huang, Yi-Chia;Chien-ning, Huang
    Contributors: 中山醫學院營養學系
    Keywords: 代謝症候群;B-維生素;發炎反應;脂質過氧化
    Metabolic syndrome;B-vitamin;Inflammatory response;Lipid peroxidation
    Date: 2008
    Issue Date: 2010-11-24T07:49:11Z (UTC)
    Abstract: 代謝症候群指標中，最簡易測量的指標─腹部肥胖，已被證實與許多發炎反應及脂質過
    氧化指標具相關性。近年來，B-維生素〈維生素B-6、B-12、葉酸〉與發炎反應或脂質
    代謝的關係也被廣泛討論。因此，本研究目的是探討代謝症候群患者的B-維生素與發
    炎反應及脂質過氧化指標的相關性。本橫斷面研究是依據行政院衛生署國民健康局之代
    謝症候群定義，由台中市中山醫學大學附設醫院新陳代謝科募集55 位代謝症候群受試
    者。代謝症候群受試者依其是否具有腹部肥胖指標（男性腰圍90 cm，女性腰圍80
    cm）分為：腹部肥胖組（共42 人）及非腹部肥胖組（共13 人）。受試者接受體位測
    量及抽取空腹血液，分析臨床血液生化值、血清葉酸與維生素B-12、血漿維生素B-6
    （磷酸比哆醛）、發炎反應指標〈高敏感度C-反應蛋白、白細胞介素6、纖維蛋白〉及
    脂質過氧化指標〈氧化型低密度脂蛋白、硫代巴比妥酸反應物）。研究結果顯示，非腹
    部肥胖組的血漿磷酸比哆醛濃度（78.4 ± 40.5 vs. 53.1 ± 34.1 nmol/L）顯著高於腹部肥胖
    組；高敏感度C-反應蛋白（0.1 ± 0.1 vs. 0.4 ± 0.4 mg/dL）及纖維蛋白（287.2 ± 75.9 vs.
    350.1 ± 72.5 mg/dL）則顯著低於腹部肥胖組。血清葉酸、維生素B-12 與脂質過氧化指
    標在兩組間則無顯著差異。腹部肥胖組的血漿磷酸比哆醛與高敏感度C-反應蛋白（r =
    -0.31, p = 0.045），非腹部肥胖組的血漿磷酸比哆醛與白細胞介素6（r = -0.57, p = 0.044）
    皆呈顯著負相關。但血清葉酸及維生素B-12 與發炎反應及脂質過氧化指標在任何一組
    皆無顯著相關性。當所有受試者合併分析後，血漿磷酸比哆醛與高敏感度C-反應蛋白
    （r = -0.40, p = 0.003）仍呈顯著負相關。代謝症候群具腹部肥胖指標的受試者有顯著較
    低的血漿磷酸比哆醛及較高的發炎反應指標濃度，且維生素B-6 與發炎反應指標呈顯著
    相關性。
    Central obesity is the easiest measurement among indicators of metabolic syndrome and has
    been documented to be related to inflammatory response and lipid peroxidation. Recently, the
    relationship between B-vitamins (vitamin B-6, B-12 and folate) and inflammatory responses
    and lipid peroxidation has been widely discussed. This cross-sectional study was undertaken
    to study the relationship between B-vitamins and inflammatory responses and lipid
    peroxidation in metabolic syndrome. The inclusion criteria of metabolic syndrome was based
    on Bureau of Health Promotion, Department of Health in Taiwan. Fifty-five subjects with
    metabolic syndrome were recruited from the division of Metabolism, Chung Shan Medical
    University hospital, Taichung. Subjects were further divided into either central obesity group
    (n = 42) or non-central obesity (n = 13) according to whether subjects having abdominal
    obesity (waist circumference 90 cm in men; 80 cm in women). Subjects’ weight and
    height were measured and body mass index was then calculated. Fasting blood sample was
    obtained to estimate hematological parameters, serum B-12 and folate, plasma B-6 (pyridoxal
    5’-phosphate, PLP), inflammatory (high-sensitivity C-reactive protein, hs-CRP; interleukin-6,
    IL-6; fibrinogen) and lipid peroxidation indicators (thiobarbituric acid reactive substances,
    TBARs; oxidized low-density lipoprotein cholesterol, ox-LDL). Results showed that plasma
    PLP concentration (78.4 ± 40.5 vs. 53.1 ± 34.1 nmol/L) was significantly higher in the
    non-central obesity group than did in the central obesity group; while levels of hs-CRP (0.1 ±
    0.1 vs. 0.4 ± 0.4 mg/dL) and fibrinogen (287.2 ± 75.9 vs. 350.1 ± 72.5 mg/dL) were
    significantly lower in the non-central obesity group than did in the central obesity group.
    There were no significant differences in serum B-12 and folate, inflammatory and lipid
    peroxidition indicators between two groups. Plasma PLP was negatively correlated with
    hs-CRP (r = -0.31, p = 0.045) in the central obesity group and with IL-6 (r = -0.57, p = 0.044)
    in the non-central obesity group. No significant correlation was found between vitamin B-12
    or folate and inflammatory responses or lipid peroxidation indicators in any groups. Negative
    correlation still remained between plasma PLP and hs-CRP after subjects were pooled (r =
    -0.40, p = 0.003). Metabolic syndrome subjects with central obesity had significantly lower
    plasma PLP and higher inflammatory response indicators; in addition, plasma PLP had a
    significant correlation with inflammatory responses.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/2769
    Appears in Collections:[營養學系暨碩士班] 研究計劃

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