研發一種本身具有活性且可用於非負載之骨缺失填補材料。利用溶膠凝膠法合成具有生物活性的鈣矽骨水泥，並添加高分子使其材料本身可作為可塑性骨水泥。鈣矽粉體經燒結後相的變化和材料顆粒的大小，還有材料本身經過熱重分析後所造成重量損失。鈣矽骨水泥之表面型態觀察、硬化時間和機械強度性質的分析浸泡於仿生的體液中不同時間所造成強度的變化及材料表面活性的改變。溶膠凝膠法合成鈣矽粉體利用Ca(NO3)24H2O 和 Si(OC2H5)4 (TEOS)當前趨物，然而著重在材料成骨泥之後其硬化時間的變化約為十分鐘之內，而在機械強度分析的結果得知，隨著鈣的含量增加至骨水泥 (S55) 在900℃時發現有較高徑向拉伸強度約為2.8 MPa，但為著鈣含量增加至 (S37) 此組時其強度約為1 MPa 明顯有降低的現象，所以鈣矽含量之比例將影響材料硬化後之強度，而在體外測試浸泡於仿生的體液中發現有磷灰石層的產生和強度沒有衰退的現象，也將高分子海藻酸鈉添加於材料當中也發現經過浸泡後有磷灰石層的產生，我們認為材料有好的生物活性預期可成為骨填補材料。
To researches and develops one kind of itself to have activeness also may use in reconstruction of non-stress-bearing bone filler. Ca/Si bone cement was prepared using a sol–gel method to have the biological activity bone , to increase high polymer causes its material itself to be possible to take the plastic bone cement. The surface compositional, morphological and particle size of the Ca/Si powders by scanning electron microscopy (SEM) , and caused the materials weight loss was determined by thermogravimetric. In vitro To analyze the Ca/Si bone cement surface morphological、setting time and mechanical strength was investigated by soaking in Hank’s solution for various periods. Ca/Si powder were synthesized by sol–gel process with Ca(NO3)24H2O and Si(OC2H5)4 (TEOS) as the starting materials.The Ca/Si bone cement have excellent diameter tensile strength of 2.8 MPa could be obtained at 900 ℃.The in vitro bioactivity of Ca/Si paste was investigated by soaking in Hank’s solution and showed that the Ca/Si bone cement could induce apatite layer formation and exhibit excellent mechanical performances. Our results indicated that Ca/Si bone cement paste was bioactive,and it is a progressive candidate for further investigation as injectable bone filler.
