本研究開發一具有快速硬化、生物活性之骨填補材料。藉由溶膠凝膠法合成出的鈣矽粉體，經過研磨後再與液體溶液混合形成骨水泥，除了分析粉體性質外，骨水泥浸泡於模擬體液前後之性質將為研究焦點。結果顯示溶膠凝膠法合成出的鈣矽粉體經研磨後顆粒大小約1μm，與液體混合後硬化時間最快在10 分鐘之內。骨水泥徑向拉伸最大強度為2.73 MPa。而在體外測試方面，將試片浸泡於人體模擬體液中，發現隨著時間的增加，磷灰石層形成越為明顯，並且不會造成強度衰減。而將幾丁聚醣和明膠加入骨水泥中也發現經過浸泡後會有磷灰石層的產生。因此我們認為本材料擁有良好的生物活性，並可預期成為一骨填補材料。
The aim of this study was to synthesize bone cement with fast-setting and bioactivity for bone substitute applications. The sol-gel derived calcium/silicon powders were ground, followed by mixing with liquid phase. The study focuses on characterization of the bone cement before and after immersion in physiologically simulated solution, in addition to evaluation of properties of as-prepared powders. The results indicated that the particles size of ground was about 1μm. When mixing with the liquid phase, the setting time of the cement from powder was within 10 min. The diametral tensile strength value of the bone cement neither increase with increase in calcium content nor decrease with decrease in silicon content. The highest strength value is about 2.73 MPa. Regarding in vitro testing in simulated body fluid (SBF), the formation of apatite layer was apparent with increasing immersion time. And, the immersion time did not degrade the strength of the bone cement. The addition of naturally chitosan and gelatin to ceramic cements were also induce the precipitated apatite layer. Last not the least, the presently developed cements had a good bioactivity, which are expected as a potential bone repair material.
