The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction

中山醫學大學機構典藏 CSMUIR > 中山醫學大學教師升等著作 > 文獻 > Item 310902500/25407

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题名:	The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
作者:	Chiu, Fu-Chun;Tsai, Chin-Feng;Huang, Pang-Shuo;Shih, Ching-Yu;Tsai, Mong-Hsun;Hwang, Juey-Jen;Wang, Yi-Chih;Chuang, Eric Y.;Tsai, Chia-Ti;Chang, Sheng-Nan
关键词:	myocardial infarction;acute coronary syndrome;microbiota;Selenomonadales;seleno-compound
日期:	2022-03
上传时间:	2023-03-28T07:42:19Z (UTC)
摘要:	Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/25407
显示于类别:	[中山醫學大學教師升等著作] 文獻

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