Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders

中山醫學大學機構典藏 CSMUIR > 中山醫學大學教師升等著作 > 文獻 > Item 310902500/25323

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题名:	Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders
作者:	Vincent Chin-Hung Chen;Chao-Yu Shen;Sophie Hsin-Yi Liang;Zhen-Hui Li;Ming-Hong Hsieh;Yeu-Sheng Tyan;Mong-Liang Lu;Yena Lee;Roger S. McIntyre;Jun-Cheng Weng
日期:	2017-11
上传时间:	2023-02-16T05:57:21Z (UTC)
摘要:	Major depressive disorder (MDD) is highly prevalent, recurrent, and associated with functional impairment, morbidity, and mortality. Herein, we aimed to identify disruptions in functional connectomics among subjects with MDD by using resting-state functional magnetic resonance imaging (rs-fMRI). Sixteen subjects with MDD and thirty health controls completed resting-state fMRI scans and clinical assessments (e.g., Hamilton Depression Rating Scale (HAMD) and Hospital Anxiety and Depression Scale (HADS)). We found higher amplitude of low frequency fluctuations (ALFF) bilaterally in the hippocampus and amygdala among MDD subjects when compared to healthy controls. Using graph theoretical analysis, we found decreased clustering coefficient, local efficiency, and transitivity in the MDD patients. Our findings suggest a potential biomarker for differentiating individuals with MDD from individuals without MDD. Keywords: Functional connectome, Graph theoretical analysis, Resting-state functional magnetic resonance imaging, Major depressive disorder
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/25323
显示于类别:	[中山醫學大學教師升等著作] 文獻

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