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請使用永久網址來引用或連結此文件:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/25115
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| 題名: | Mulberry fruit extract prevents liver fibrosis via inhibition of inflammation in DEN-treated rats |
| 作者: | Huang, Yun-Ching Chang ； Chau-Jong Wang ； Chun-Jung Lai ； Hui-Pei |
| 貢獻者: | 中山醫學大學 |
| 日期: | 2021-12-01 |
| 上傳時間: | 2022-10-21T03:17:41Z (UTC)
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| 出版者: | 研發處育成中心暨產學合作組 |
| 摘要: | Liver disease, which involves an extensive range of liver pathologies from fatty liver to hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma, is a serious health problem around the world. Mulberry fruits are rich in polyphenols and have been reported to remove free radicals and mitigate inflammation in the presence of gastric cancer, melanoma, leukemia, or liver injury induced by alcohol or carbon tetrachloride (CCl_4). Our previous results have demonstrated the beneficial effects of mulberry water extract (MWE) on hepatocarcinogenesis via phosphoinositide 3-kinase (PI3K)/phosphorylated protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) inhibition and cell death-related proteins. The purpose of this study was to assess the anti-inflammatory effect of MWE on liver cancer-related fibrosis in diethylnitrosamine (DEN)-induced rats. Oral treatment with different concentrations of MWE reduced α-smooth muscle actin (α-SMA, fibrosis marker) in DEN-induced rats. Compared with the DEN-induced group, MWE significantly increased anti-oxidative enzyme activities. Rats receiving MWE supplementation showed reduced interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α levels compared to untreated DEN-induced rats. Inflammatory and fibrotic proteins such as collagen IV, fibronectin, phosphorylated signal transducer and activator of transcription (STAT)3, PI3K, Akt, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were also inhibited by MWE treatment in DEN-induced rats. These results indicated that MWE is a potential health supplement for preventing liver fibrosis and hepatocarcinogenesis. |
| URI: | https://ir.csmu.edu.tw:8080/handle/310902500/25115 |
| 關聯: | 中山醫學雜誌 ； 32卷1期 (2021 / 06 / 01) ， P1 - 9 |
| 顯示於類別: | [研發處] 期刊論文
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| Mulberry fruit extract prevents liver fibrosis via inhibition of inflammation in DEN-treated rats.pdf | | 990Kb | Adobe PDF | 90 | 檢視/開啟 |
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