New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence

doi:10.1007/s10555-020-09845-2

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 其他文獻 > Item 310902500/25041

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/25041

Title:	New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence
Authors:	Lu, KH;Lin, CW;Hsieh, YH;Su, SC;Reiter, RJ;Yang, SF
Keywords:	Adolescence;Childhood;Melatonin;Metastasis;Sarcoma
Date:	2020
Issue Date:	2022-08-09T09:27:28Z (UTC)
Publisher:	SPRINGER
ISSN:	0167-7659
Abstract:	Melatonin is an indole produced by the pineal gland at night under normal light or dark conditions, and its levels, which are higher in children than in adults, begin to decrease prior to the onset of puberty and continue to decline thereafter. Apart from circadian regulatory actions, melatonin has significant apoptotic, angiogenic, oncostatic, and antiproliferative effects on various cancer cells. Particularly, the ability of melatonin to inhibit skeletomuscular sarcoma, which most commonly affects children, teenagers, and young adults, is substantial. In the past few decades, the vast majority of references have focused on the concept of epithelial-mesenchymal transition involvement in invasion and migration to allow carcinoma cells to dissociate from each other and to degrade the extracellular matrix. Recently, researchers have applied this idea to sarcoma cells of mesenchymal origin, e.g., osteosarcoma and Ewing sarcoma, with their ability to initiate the invasion-metastasis cascade. Similarly, interest of the effects of melatonin has shifted from carcinomas to sarcomas. Herein, in this state-of-the-art review, we compiled the knowledge related to the molecular mechanism of antimetastatic actions of melatonin on skeletomuscular sarcoma as in childhood and during adolescence. Utilization of melatonin as an adjuvant with chemotherapeutic drugs for synergy and fortification of the antimetastatic effects for the reinforcement of therapeutic actions are considered.
URI:	http://dx.doi.org/10.1007/s10555-020-09845-2 https://www.webofscience.com/wos/woscc/full-record/WOS:000517421300001 https://ir.csmu.edu.tw:8080/handle/310902500/25041
Relation:	CANCER AND METASTASIS REVIEWS ,2020 ,v39 ,issue 1 ,p303-320
Appears in Collections:	[中山醫學大學研究成果] 其他文獻

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	248	View/Open

Loading...