Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome

doi:10.1016/j.jacc.2019.10.057

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24946

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题名:	Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
作者:	Bittner, VA;Szarek, M;Aylward, PE;Bhatt, DL;Diaz, R;Edelberg, JM;Fras, Z;Goodman, SG;Halvorsen, S;Hanotin, C;Harrington, RA;Jukema, JW;Loizeau, V;Moriarty, PM;Moryusef, A;Pordy, R;Roe, MT;Sinnaeve, P;Tsimikas, S;Vogel, R;White, HD;Zahger, D;Zeiher, AM;Steg, G;Schwartz, GG;Aylward, PE;Drexel, H;Sinnaeve, P;Dilic, M;Lopes, RD;Gotcheva, NN;Goodman, SG;Prieto, JC;Yong, H;Lopez-Jaramillo, P;Pecin, I;Reiner, Z;Ostadal, P;Poulsen, SH;Viigimaa, M;Nieminen, MS;Danchin, N;Chumburidze, V;Marx, N;Liberopoulos, E;Valdovinos, PCM;Tse, HF;Kiss, RG;Xavier, D;Zahger, D;Valgimigli, M;Kimura, T;Kim, HS;Kim, SH;Erglis, A;Laucevicius, A;Kedev, S;Yusoff, K;Lopez, GAR;Alings, M;Halvorsen, S;Flores, RMC;Sy, RG;Budaj, A;Morais, J;Dorobantu, M;Karpov, Y;Ristic, AD;Chua, T;Murin, J;Fras, Z;Dalby, AJ;Tunon, J;de Silva, HA;Hagstrom, E;Muller, C;Chiang, CE;Sritara, P;Guneri, S;Parkhomenko, A;Ray, KK;Moriarty, PM;Vogel, R;Chaitman, B;Kelsey, SF;Olsson, AG;Rouleau, JL;Simoons, ML;Alexander, K;Meloni, C;Rosenson, R;Sijbrands, EJG;Alexander, JH;Armaganijan, L;Bagai, A;Bahit, MC;Brennan, JM;Clifton, S;DeVore, AD;Deloatch, S;Dickey, S;Dombrowski, K;Ducrocq, G;Eapen, Z;Endsley, P;Eppinger, A;Hess, CN;Hlatky, MA;Jordan, JD;Knowles, JW;Kolls, BJ;Kong, DF;Leonardi, S;Lillis, L;Lopes, RD;Maron, DJ;Marcus, J;Mathews, R;Mehta, RH;Mentz, RJ;Moreira, HG;Patel, CB;Pereira, SB;Perkins, L;Povsic, TJ;Puymirat, E;Jones, WS;Shah, BR;Sherwood, MW;Stringfellow, K;Sujjavanich, D;Toma, M;Trotter, C;van Diepen, SFP;Wilson, MD;Yan, ATK;Schiavi, LB;Garrido, M;Alvarisqueta, AF;Sassone, SA;Bordonava, AP;De Lima, AEA;Schmidberg, JM;Duronto, EA;Caruso, OC;Novaretto, LP;Hominal, MA;Montana, OR;Caccavo, A;Vilamajo, OAG;Lorenzatti, AJ;Cartasegna, LR;Paterlini, GA;Mackinnon, IJ;Caime, GD;Amuchastegui, M;Codutti, OR;Jure, HO;Bono, JOE;Hrabar, AD;Vallejos, JA;Rodolfo, AAG;Novoa, F;Patocchi, CA;Zaidman, CJ;Giuliano, ME;Dran, RD;Vico, ML;Carnero, GS;Guzman, PN;Allende, JCM;Brasca, DFG;Labarta, MHB;Nani, S;Blumberg, EDS;Colombo, HR;Liberman, A;Luciardi, HL;Waisman, GD;Berli, MA;Duran, ROG;Cestari, HG;Luquez, HA;Giordano, JA;Saavedra, SS;Waites, JH;Collins, N;Soward, A;Hii, CLS;Shaw, J;Arstall, MA;Horowitz, J;Rogers, JF;Colquhoun, D;Flores, REO;Roberts-Thomson, P;Raffel, O;Lehman, SJ;Coverdale, SGM;Garrahy, PJ;Starmer, G;Sader, M;Carroll, PA;Zweiker, R;Hoppe, U;Huber, K;Berger, R;Weidinger, F;Faes, D;Hermans, K;Pirenne, B;Leone, A;Hoffer, E;Vrolix, MCM;De Wolf, L;Wollaert, B;Castadot, M;Dujardin, K;Beauloye, C;Vervoort, G;Striekwold, H;Convens, C;Roosen, J;Barbato, E;Claeys, M;Cools, F;Terzic, I;Barakovic, F;Midzic, Z;Pojskic, B;Fazlibegovic, E;Durak-Nalbantic, A;Vulic, D;Muslibegovic, A;Reis, G;Sousa, L;Nicolau, JC;Giorgeto, FE;Silva, RP;Maia, LN;Rech, R;Rossi, PRF;Cerqueira, MJAG;Duda, N;Kalil, R;Kormann, A;Abrantes, JAM;Pimentel, P;Soggia, AP;de Santos, MON;Neuenschwander, F;Bodanese, LC;Michalaros, YL;Eliaschewitz, FG;Vidotti, MH;Leaes, PE;Botelho, RV;Kaiser, S;Manenti, ERFF;Precoma, DB;Jorge, JCM;Silva, PGMD;Silveira, JA;Saporito, W;Marin, JA;Feitosa, GS;Ritt, LEF;de Souza, JA;Costa, F;Souza, WKSB;Reis, HJL;Lopes, RD;Machado, L;Ayoub, JCA;Todorov, GV;Nikolov, FP;Velcheva, ES;Tzekova, ML;Benov, HO;Petranov, SL;Tumbev, HS;Shehova-Yankova, NS;Markov, DT;Raev, DH;Mollov, MN;Kichukov, KN;Ilieva-Pandeva, KA;Gotcheva, NN;Ivanova, R;Mincheva, VM;Lazov, PV;Dimov, BI;Senaratne, M;Stone, J;Kornder, J;Pearce, S;Dion, D;Savard, D;Pesant, Y;Pandey, A;Robinson, S;Gosselin, G;Vizel, S;Hoag, G;Bourgeois, R;Morisset, A;Sabbah, E;Sussex, B;Kouz, S;MacDonald, P;Diaz, A;Michaud, N;Fell, D;Leung, R;Vuurmans, T;Lai, C;Nigro, F;Davies, R;Nogareda, G;Vijayaraghavan, R;Ducas, J;Lepage, S;Mehta, S;Cha, J;Dupuis, R;Fong, P;Rodes-Cabau, J;Fadlallah, H;Cleveland, D;Huynh, T;Bata, I;Hameed, A;Pincetti, C;Potthoff, S;Acevedo, M;Aguirre, A;Vejar, M;Yanez, M;Araneda, G;Fernandez, M;Perez, L;Varleta, P;Florenzano, F;Huidobro, L;Raffo, CA;Olivares, C;Chen, JY;Dong, YG;Huang, WJ;Wang, JZ;Huang, SA;Yao, ZH;Cui, L;Lin, WH;Sun, YM;Wang, JF;Li, JP;Zhang, XL;Zhu, H;Chen, DD;Huang, L;Dong, SH;Su, GH;Xu, B;Su, X;Cheng, XS;Lin, JX;Zong, WX;Li, HM;Feng, Y;Xu, DL;Yang, XC;Ke, YN;Lin, XF;Zhang, Z;Zheng, ZQ;Luo, ZR;Chen, YD;Ding, CH;Zheng, Y;Li, XD;Peng, DQ;Li, Y;Wei, M;Liu, SW;Yu, YH;Qu, BM;Jiang, WH;Zhou, YJ;Zhao, XS;Yuan, ZY;Guo, Y;Xu, XP;Shi, XB;Ge, JB;Fu, GS;Bai, F;Fang, WY;Shou, XL;Yang, XJ;Wang, JA;Jaramillo, N;Vallejo, GS;Botia, DCL;Lopez, RB;De Salazar, DIM;Bonfanti, AJC;Higuera, JD;Silva, SIB;Lozada, HJG;Arroyo, JAC;Mendoza, JLA;Ruiz, RLF;Fernandez, AM;Jatin, FGM;Herazo, AS;Parada, JC;Triana, MAU;Spinar, J;Horak, D;Stasek, J;Alan, D;Machova, V;Linhart, A;Novotny, V;Kaucak, V;Rokyta, R;Naplava, R;Coufal, Z;Adamkova, V;Podpera, I;Zizka, J;Motovska, Z;Marusincova, I;Svab, P;Heinc, P;Kuchar, J;Povolny, P;Raungaard, B;Clemmensen, P;Bang, LE;May, O;Bottcher, M;Hove, JD;Frost, L;Gislason, G;Larsen, J;Johansen, PB;Hald, F;Jeppesen, J;Nielsen, T;Kristensen, KS;Walichiewicz, PM;Lomholdt, JD;Klausen, IC;Nielsen, PK;Davidsen, F;Videbaek, L;Soots, M;Vahula, V;Hedman, A;Soopold, U;Martsin, K;Taskinen, MR;Porthan, K;Airaksinen, JK;Juonala, M;Kiviniemi, T;Vikman, S;Posio, P;Taurio, J;Huikuri, H;Kaikkonen, K;Coste, P;Ferrari, E;Morel, O;Montalescot, G;Barone-Rochette, G;Mansourati, J;Cottin, Y;Steg, PG;Leclercq, F;Belhassane, A;Delarche, N;Boccara, F;Paganelli, F;Clerc, J;Schiele, F;Aboyans, V;Probst, V;Berland, J;Lefevre, T;Khintibidze, I;Shaburishvili, T;Pagava, Z;Ghlonti, R;Lominadze, Z;Khabeishvili, G;Hemetsberger, R;Rauch-Krohnert, U;Stratmann, M;Appel, KF;Schmidt, E;Omran, H;Stellbrink, C;Dorsel, T;Lianopoulos, E;Marx, R;Zirlik, A;Schellenberg, D;Heitzer, T;Laufs, U;Marx, N;Gielen, S;Winkelmann, B;Behrens, S;Sydow, K;Simonis, G;Muenzel, T;Werner, N;Leggewie, S;Bocker, D;Braun-Dullaeus, R;Toursarkissian, N;Jeserich, M;Weissbrodt, M;Schaeufele, T;Weil, J;Voller, H;Waltenberger, J;Natour, M;Steiner, S;Heidenreich, L;Gremmler, U;Killat, H;Patsilinakos, S;Kartalis, A;Manolis, A;Sionis, D;Liberopoulos, E;Skoumas, I;Athyros, V;Parthenakis, PIF;Hahalis, PIG;Lekakis, J;Xatzitolios, A;Ovando, SRF;Valdovinos, PCM;Benecke, JLA;De Leon, ERR;Yan, BPY;Siu, DCW;Turi, T;Merkely, B;Kiss, RG;Ungi, I;Lupkovics, G;Nagy, L;Katona, A;Edes, I;Muller, G;Horvath, I;Kapin, T;Falukozy, J;Kumbla, M;Sandhu, M;Annam, S;Proddutur, NR;Premchand, RK;Mahajan, A;Abhyanakar, AD;Kerkar, P;Govinda, RA;Oomman, A;Sinha, D;Patil, SN;Kahali, D;Sawhney, J;Joshi, AB;Chaudhary, S;Harkut, P;Guha, S;Porwal, S;Jujjuru, S;Pothineni, RB;Monteiro, MR;Khan, A;Iyengar, SS;Grewal, JS;Chopda, M;Fulwani, MC;Patange, A;Chopra, VK;Goyal, NK;Shinde, R;Manakshe, GV;Patki, N;Sethi, S;Munusamy, V;Karna, S;Adhyapak, S;Pandurangi, U;Mathur, R;Kalashetti, S;Bhagwat, A;Raghuraman, B;Yerra, SK;Bhansali, P;Borse, R;Das, S;Abdullakutty, J;Saathe, S;Palimkar, P;Atar, S;Shechter, M;Mosseri, M;Arbel, Y;Lotan, C;Rosenschein, U;Katz, A;Henkin, Y;Francis, A;Klutstein, M;Nikolsky, E;Turgeman, Y;Halabi, M;Kornowski, R;Jonas, M;Amir, O;Rozenman, Y;Fuchs, S;Hussein, O;Gavish, D;Vered, Z;Caraco, Y;Elias, M;Tov, N;Piovaccari, G;De Pellegrin, A;Guardigli, G;Licciardello, G;Auguadro, C;Cuccia, C;Salvioni, A;Musumeci, G;Calabro, P;Novo, S;Faggiano, P;De Cesare, NB;Berti, S;Cavallini, C;Puccioni, E;Galvani, M;Tespili, M;Piatti, P;Palvarini, M;De Luca, G;Violini, R;De Leo, A;Filardi, PP;Ferratini, M;Dai, K;Kamiya, H;Ando, K;Takeda, Y;Morino, Y;Hata, Y;Kimura, K;Kishi, K;Michishita, I;Uehara, H;Higashikata, T;Hirayama, A;Hirooka, K;Sakagami, S;Taguchi, S;Koike, A;Fujinaga, H;Koba, S;Kozuma, K;Kawasaki, T;Ono, Y;Shimizu, M;Katsuda, Y;Wada, A;Shinke, T;Ako, J;Fujii, K;Takahashi, T;Sakamoto, T;Furukawa, Y;Sugino, H;Mano, T;Utsu, N;Ito, K;Haraguchi, T;Ueda, Y;Nishibe, A;Fujimoto, K;Yoon, JH;Park, HS;Chae, IH;Kim, MH;Jeong, MH;Rha, S;Kim, C;Hong, T;Busmane, A;Pontaga, N;Strelnieks, A;Mintale, I;Sime, I;Petrulioniene, Z;Kavaliauskiene, R;Jurgaitiene, R;Sakalyte, G;Slapikas, R;Norkiene, S;Misonis, N;Kibarskis, A;Kubilius, R;Bojovski, S;Lozance, N;Kjovkaroski, A;Doncovska, S;Ong, TK;Kasim, S;Maskon, O;Kandasamy, B;Liew, HB;Mohamed, WMIW;Castillo, AG;Calvillo, JC;Campos, PF;Fragoso, JCN;Llamas, EAB;Gamba, MAA;Madrigal, JC;Salas, LGG;Rosas, EL;Diaz, BG;Vazquez, ES;Ackar, AN;Esperon, GAL;Sanchez, CRM;De Leon, MG;Otero, RS;Salmon, GF;Rios, JAP;Ruiz, JAG;Breedveld, RW;Hoogslag, PAM;Suryapranata, H;Oomen, A;Wiersma, JJ;Van Der Wal, RMA;Van Huysduynen-Monraats, PSH;Karalis, I;Verdel, GJE;Brueren, BRG;Troquay, RPT;Viergever, EP;Al-Windy, NYY;Bartels, GL;Cornel, JH;Hermans, WRM;Herrman, JPR;Bos, RJ;Groutars, RGEJ;Van Der Zwaan, CC;Kaplan, R;Ronner, E;Groenemeijer, BE;Bronzwaer, PNA;Liem, AAH;Rensing, BJWM;Bokern, MJJA;Nijmeijer, R;Hersbach, FMRJ;Willems, FF;Gosselink, ATM;Elliott, J;Wilkins, G;Fisher, R;Scott, D;Hart, H;Stewart, R;Harding, S;Ternouth, I;Fisher, N;Aitken, D;Anscombe, R;Tomala, T;Nygard, O;Sparby, JA;Andersen, K;Gullestad, L;Jortveit, J;Munk, PS;Hurtig, U;Ticona, JRC;Velasquez, JRD;Miguel, 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A;Zrazhevsky, K;Vishnevsky, AY;Gurevich, V;Stryuk, R;Lomakin, NV;Bokarev, I;Shalaev, S;Khaisheva, L;Chizhov, P;Viktorova, I;Osokina, N;Akatova, E;Chumakova, G;Libov, I;Voevoda, MI;Tretyakova, TV;Baranov, E;Shustov, S;Yakushin, S;Gordeev, I;Khasanov, N;Reshetko, O;Sotnikova, T;Molchanova, O;Nikolaev, K;Gapon, L;Baranova, E;Shogenov, Z;Kosmachova, E;Karpov, Y;Povzun, A;Egorova, L;Tyrenko, VV;Ivanov, IG;Simic, D;Ivanovic, N;Davidovic, G;Tasic, N;Asanin, MR;Stojic, S;Apostolovic, SR;Ilic, S;Putnikovic, B;Stankovic, A;Arandjelovic, A;Radovanovic, S;Balinovac, J;Dincic, DV;Seferovic, P;Dodic, S;Dimkovic, S;Poh, KK;Ong, HY;Micko, K;Nociar, J;Pella, D;Fulop, P;Hranai, M;Palka, J;Mazur, J;Majercak, I;Dzupina, A;Fazekas, F;Gonsorcik, J;Bugan, V;Selecky, J;Kamensky, G;Strbova, J;Smik, R;Dukat, A;Zuran, I;Oklukar, J;Suligoj, NC;Cevc, M;Lipar, L;Cyster, HP;Ranjith, N;Corbett, C;Bayat, J;Makotoko, EM;Kapp, IE;Basson, MMD;Lottering, H;Van Zyl, LJ;Sebastian, PJ;Pillay, T;Saaiman, JA;Commerford, 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关键词:	acute coronary syndromes;alirocumab;low-density lipoprotein cholesterol;major adverse cardiovascular events;proprotein convertase subtilisin/kexin type 9 inhibition
日期:	2020
上传时间:	2022-08-09T08:10:42Z (UTC)
出版者:	ELSEVIER SCIENCE INC
ISSN:	0735-1097
摘要:	BACKGROUND Lipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C). OBJECTIVES A pre-specified analysis of the placebo-controlled ODYSSEY Outcomes trial in patients with recent acute coronary syndrome (ACS) determined whether alirocumab-induced changes in lipoprotein(a) and LDL-C independently predicted major adverse cardiovascular events (MACE). METHODS One to 12 months after ACS, 18,924 patients on high-intensity statin therapy were randomized to alirocumab or placebo and followed for 2.8 years (median). Lipoprotein(a) was measured at randomization and 4 and 12 months thereafter. The primary MACE outcome was coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina. RESULTS Baseline lipoprotein(a) levels (median: 21.2 mg/dl; interquartile range [IQR]: 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE. Alirocumab reduced lipoprotein(a) by 5.0 mg/dl (IQR: 0 to 13.5 mg/dl), corrected LDL-C by 51.1 mg/dl (IQR: 33.7 to 67.2 mg/dl), and reduced the risk of MACE (hazard ratio [HR]: 0.85; 95% confidence interval [CI]: 0.78 to 0.93). Alirocumab-induced reductions of lipoprotein(a) and corrected LDL-C independently predicted lower risk of MACE, after adjustment for baseline concentrations of both lipoproteins and demographic and clinical characteristics. A 1-mg/dl reduction in lipoprotein(a) with alirocumab was associated with a HR of 0.994 (95% CI: 0.990 to 0.999; p = 0.0081). CONCLUSIONS Baseline lipoprotein(a) and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS. Lipoprotein(a) lowering by alirocumab is an independent contributor to MACE reduction, which suggests that lipoprotein(a) should be an independent treatment target after ACS. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
URI:	http://dx.doi.org/10.1016/j.jacc.2019.10.057 https://www.webofscience.com/wos/woscc/full-record/WOS:000506877300001 https://ir.csmu.edu.tw:8080/handle/310902500/24946
關聯:	JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY ,2020 ,v75 ,issue 2 ,p133-144
显示于类别:	[中山醫學大學研究成果] 期刊論文

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