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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24946


    Title: Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
    Authors: Bittner, VA;Szarek, M;Aylward, PE;Bhatt, DL;Diaz, R;Edelberg, JM;Fras, Z;Goodman, SG;Halvorsen, S;Hanotin, C;Harrington, RA;Jukema, JW;Loizeau, V;Moriarty, PM;Moryusef, A;Pordy, R;Roe, MT;Sinnaeve, P;Tsimikas, S;Vogel, R;White, HD;Zahger, D;Zeiher, AM;Steg, G;Schwartz, GG;Aylward, PE;Drexel, H;Sinnaeve, P;Dilic, M;Lopes, RD;Gotcheva, NN;Goodman, SG;Prieto, JC;Yong, H;Lopez-Jaramillo, P;Pecin, I;Reiner, Z;Ostadal, P;Poulsen, SH;Viigimaa, M;Nieminen, MS;Danchin, N;Chumburidze, V;Marx, N;Liberopoulos, E;Valdovinos, PCM;Tse, HF;Kiss, RG;Xavier, D;Zahger, D;Valgimigli, M;Kimura, T;Kim, HS;Kim, SH;Erglis, A;Laucevicius, A;Kedev, S;Yusoff, K;Lopez, GAR;Alings, M;Halvorsen, S;Flores, RMC;Sy, RG;Budaj, A;Morais, J;Dorobantu, M;Karpov, Y;Ristic, AD;Chua, T;Murin, J;Fras, Z;Dalby, AJ;Tunon, J;de Silva, HA;Hagstrom, E;Muller, C;Chiang, CE;Sritara, P;Guneri, S;Parkhomenko, A;Ray, KK;Moriarty, PM;Vogel, R;Chaitman, B;Kelsey, SF;Olsson, AG;Rouleau, JL;Simoons, ML;Alexander, K;Meloni, C;Rosenson, R;Sijbrands, EJG;Alexander, JH;Armaganijan, L;Bagai, A;Bahit, MC;Brennan, JM;Clifton, S;DeVore, AD;Deloatch, S;Dickey, S;Dombrowski, K;Ducrocq, G;Eapen, Z;Endsley, P;Eppinger, A;Hess, CN;Hlatky, MA;Jordan, JD;Knowles, JW;Kolls, BJ;Kong, DF;Leonardi, S;Lillis, L;Lopes, RD;Maron, DJ;Marcus, J;Mathews, R;Mehta, RH;Mentz, RJ;Moreira, HG;Patel, CB;Pereira, SB;Perkins, L;Povsic, TJ;Puymirat, E;Jones, WS;Shah, BR;Sherwood, MW;Stringfellow, K;Sujjavanich, D;Toma, M;Trotter, C;van Diepen, SFP;Wilson, MD;Yan, ATK;Schiavi, LB;Garrido, M;Alvarisqueta, AF;Sassone, SA;Bordonava, AP;De Lima, AEA;Schmidberg, JM;Duronto, EA;Caruso, OC;Novaretto, LP;Hominal, MA;Montana, OR;Caccavo, A;Vilamajo, OAG;Lorenzatti, AJ;Cartasegna, LR;Paterlini, GA;Mackinnon, IJ;Caime, GD;Amuchastegui, M;Codutti, OR;Jure, HO;Bono, JOE;Hrabar, AD;Vallejos, JA;Rodolfo, AAG;Novoa, F;Patocchi, CA;Zaidman, CJ;Giuliano, ME;Dran, RD;Vico, ML;Carnero, GS;Guzman, PN;Allende, JCM;Brasca, DFG;Labarta, MHB;Nani, S;Blumberg, EDS;Colombo, HR;Liberman, A;Luciardi, HL;Waisman, GD;Berli, MA;Duran, ROG;Cestari, HG;Luquez, HA;Giordano, JA;Saavedra, SS;Waites, JH;Collins, N;Soward, A;Hii, CLS;Shaw, J;Arstall, MA;Horowitz, J;Rogers, JF;Colquhoun, D;Flores, REO;Roberts-Thomson, P;Raffel, O;Lehman, SJ;Coverdale, SGM;Garrahy, PJ;Starmer, G;Sader, M;Carroll, PA;Zweiker, R;Hoppe, U;Huber, K;Berger, R;Weidinger, F;Faes, D;Hermans, K;Pirenne, B;Leone, A;Hoffer, E;Vrolix, MCM;De Wolf, L;Wollaert, B;Castadot, M;Dujardin, K;Beauloye, C;Vervoort, G;Striekwold, H;Convens, C;Roosen, J;Barbato, E;Claeys, M;Cools, F;Terzic, I;Barakovic, F;Midzic, Z;Pojskic, B;Fazlibegovic, E;Durak-Nalbantic, A;Vulic, D;Muslibegovic, A;Reis, G;Sousa, L;Nicolau, JC;Giorgeto, FE;Silva, RP;Maia, LN;Rech, R;Rossi, PRF;Cerqueira, MJAG;Duda, N;Kalil, R;Kormann, A;Abrantes, JAM;Pimentel, P;Soggia, AP;de Santos, MON;Neuenschwander, F;Bodanese, LC;Michalaros, YL;Eliaschewitz, FG;Vidotti, MH;Leaes, PE;Botelho, RV;Kaiser, S;Manenti, ERFF;Precoma, DB;Jorge, JCM;Silva, PGMD;Silveira, JA;Saporito, W;Marin, JA;Feitosa, GS;Ritt, LEF;de Souza, JA;Costa, F;Souza, WKSB;Reis, HJL;Lopes, RD;Machado, L;Ayoub, JCA;Todorov, GV;Nikolov, FP;Velcheva, ES;Tzekova, ML;Benov, HO;Petranov, SL;Tumbev, HS;Shehova-Yankova, NS;Markov, DT;Raev, DH;Mollov, MN;Kichukov, KN;Ilieva-Pandeva, KA;Gotcheva, NN;Ivanova, R;Mincheva, VM;Lazov, PV;Dimov, BI;Senaratne, M;Stone, J;Kornder, J;Pearce, S;Dion, D;Savard, D;Pesant, Y;Pandey, A;Robinson, S;Gosselin, G;Vizel, S;Hoag, G;Bourgeois, R;Morisset, A;Sabbah, E;Sussex, B;Kouz, S;MacDonald, P;Diaz, A;Michaud, N;Fell, D;Leung, R;Vuurmans, T;Lai, C;Nigro, F;Davies, R;Nogareda, G;Vijayaraghavan, R;Ducas, J;Lepage, S;Mehta, S;Cha, J;Dupuis, R;Fong, P;Rodes-Cabau, J;Fadlallah, H;Cleveland, D;Huynh, T;Bata, I;Hameed, A;Pincetti, C;Potthoff, S;Acevedo, M;Aguirre, A;Vejar, M;Yanez, M;Araneda, G;Fernandez, M;Perez, L;Varleta, P;Florenzano, F;Huidobro, L;Raffo, CA;Olivares, C;Chen, JY;Dong, YG;Huang, WJ;Wang, JZ;Huang, SA;Yao, ZH;Cui, L;Lin, WH;Sun, YM;Wang, JF;Li, JP;Zhang, XL;Zhu, H;Chen, DD;Huang, L;Dong, SH;Su, GH;Xu, B;Su, X;Cheng, XS;Lin, JX;Zong, WX;Li, HM;Feng, Y;Xu, DL;Yang, XC;Ke, YN;Lin, XF;Zhang, Z;Zheng, ZQ;Luo, ZR;Chen, YD;Ding, CH;Zheng, Y;Li, XD;Peng, DQ;Li, Y;Wei, M;Liu, SW;Yu, YH;Qu, BM;Jiang, WH;Zhou, YJ;Zhao, XS;Yuan, ZY;Guo, Y;Xu, XP;Shi, XB;Ge, JB;Fu, GS;Bai, F;Fang, WY;Shou, XL;Yang, XJ;Wang, JA;Jaramillo, N;Vallejo, GS;Botia, DCL;Lopez, RB;De Salazar, DIM;Bonfanti, AJC;Higuera, JD;Silva, SIB;Lozada, HJG;Arroyo, JAC;Mendoza, JLA;Ruiz, RLF;Fernandez, AM;Jatin, FGM;Herazo, AS;Parada, JC;Triana, MAU;Spinar, J;Horak, D;Stasek, J;Alan, D;Machova, V;Linhart, A;Novotny, V;Kaucak, V;Rokyta, R;Naplava, R;Coufal, Z;Adamkova, V;Podpera, I;Zizka, J;Motovska, Z;Marusincova, I;Svab, P;Heinc, P;Kuchar, J;Povolny, P;Raungaard, B;Clemmensen, P;Bang, LE;May, O;Bottcher, M;Hove, JD;Frost, L;Gislason, G;Larsen, J;Johansen, PB;Hald, F;Jeppesen, J;Nielsen, T;Kristensen, KS;Walichiewicz, PM;Lomholdt, JD;Klausen, IC;Nielsen, PK;Davidsen, F;Videbaek, L;Soots, M;Vahula, V;Hedman, A;Soopold, U;Martsin, K;Taskinen, MR;Porthan, K;Airaksinen, JK;Juonala, M;Kiviniemi, T;Vikman, S;Posio, P;Taurio, J;Huikuri, H;Kaikkonen, K;Coste, P;Ferrari, E;Morel, O;Montalescot, G;Barone-Rochette, G;Mansourati, J;Cottin, Y;Steg, PG;Leclercq, F;Belhassane, A;Delarche, N;Boccara, F;Paganelli, F;Clerc, J;Schiele, F;Aboyans, V;Probst, V;Berland, J;Lefevre, T;Khintibidze, I;Shaburishvili, T;Pagava, Z;Ghlonti, R;Lominadze, Z;Khabeishvili, G;Hemetsberger, R;Rauch-Krohnert, U;Stratmann, M;Appel, KF;Schmidt, E;Omran, H;Stellbrink, C;Dorsel, T;Lianopoulos, E;Marx, R;Zirlik, A;Schellenberg, D;Heitzer, T;Laufs, U;Marx, N;Gielen, S;Winkelmann, B;Behrens, S;Sydow, K;Simonis, G;Muenzel, T;Werner, N;Leggewie, S;Bocker, D;Braun-Dullaeus, R;Toursarkissian, N;Jeserich, M;Weissbrodt, M;Schaeufele, T;Weil, J;Voller, H;Waltenberger, J;Natour, M;Steiner, S;Heidenreich, L;Gremmler, U;Killat, H;Patsilinakos, S;Kartalis, A;Manolis, A;Sionis, D;Liberopoulos, E;Skoumas, I;Athyros, V;Parthenakis, PIF;Hahalis, PIG;Lekakis, J;Xatzitolios, A;Ovando, SRF;Valdovinos, PCM;Benecke, JLA;De Leon, ERR;Yan, BPY;Siu, DCW;Turi, T;Merkely, B;Kiss, RG;Ungi, I;Lupkovics, G;Nagy, L;Katona, A;Edes, I;Muller, G;Horvath, I;Kapin, T;Falukozy, J;Kumbla, M;Sandhu, M;Annam, S;Proddutur, NR;Premchand, RK;Mahajan, A;Abhyanakar, AD;Kerkar, P;Govinda, RA;Oomman, A;Sinha, D;Patil, SN;Kahali, D;Sawhney, J;Joshi, AB;Chaudhary, S;Harkut, P;Guha, S;Porwal, S;Jujjuru, S;Pothineni, RB;Monteiro, MR;Khan, A;Iyengar, SS;Grewal, JS;Chopda, M;Fulwani, MC;Patange, A;Chopra, VK;Goyal, NK;Shinde, R;Manakshe, GV;Patki, N;Sethi, S;Munusamy, V;Karna, S;Adhyapak, S;Pandurangi, U;Mathur, R;Kalashetti, S;Bhagwat, A;Raghuraman, B;Yerra, SK;Bhansali, P;Borse, R;Das, S;Abdullakutty, J;Saathe, S;Palimkar, P;Atar, S;Shechter, M;Mosseri, M;Arbel, Y;Lotan, C;Rosenschein, U;Katz, A;Henkin, Y;Francis, A;Klutstein, M;Nikolsky, E;Turgeman, Y;Halabi, M;Kornowski, R;Jonas, M;Amir, O;Rozenman, Y;Fuchs, S;Hussein, O;Gavish, D;Vered, Z;Caraco, Y;Elias, M;Tov, N;Piovaccari, G;De Pellegrin, A;Guardigli, G;Licciardello, G;Auguadro, C;Cuccia, C;Salvioni, A;Musumeci, G;Calabro, P;Novo, S;Faggiano, P;De Cesare, NB;Berti, S;Cavallini, C;Puccioni, E;Galvani, M;Tespili, M;Piatti, P;Palvarini, M;De Luca, G;Violini, R;De Leo, A;Filardi, PP;Ferratini, M;Dai, K;Kamiya, H;Ando, K;Takeda, Y;Morino, Y;Hata, Y;Kimura, K;Kishi, K;Michishita, I;Uehara, H;Higashikata, T;Hirayama, A;Hirooka, K;Sakagami, S;Taguchi, S;Koike, A;Fujinaga, H;Koba, S;Kozuma, K;Kawasaki, T;Ono, Y;Shimizu, M;Katsuda, Y;Wada, A;Shinke, T;Ako, J;Fujii, K;Takahashi, T;Sakamoto, T;Furukawa, Y;Sugino, H;Mano, T;Utsu, N;Ito, K;Haraguchi, T;Ueda, Y;Nishibe, A;Fujimoto, K;Yoon, JH;Park, HS;Chae, IH;Kim, MH;Jeong, MH;Rha, S;Kim, C;Hong, T;Busmane, A;Pontaga, N;Strelnieks, A;Mintale, I;Sime, I;Petrulioniene, Z;Kavaliauskiene, R;Jurgaitiene, R;Sakalyte, G;Slapikas, R;Norkiene, S;Misonis, N;Kibarskis, A;Kubilius, R;Bojovski, S;Lozance, N;Kjovkaroski, A;Doncovska, S;Ong, TK;Kasim, S;Maskon, O;Kandasamy, B;Liew, HB;Mohamed, WMIW;Castillo, AG;Calvillo, JC;Campos, PF;Fragoso, JCN;Llamas, EAB;Gamba, MAA;Madrigal, JC;Salas, LGG;Rosas, EL;Diaz, BG;Vazquez, ES;Ackar, AN;Esperon, GAL;Sanchez, CRM;De Leon, MG;Otero, RS;Salmon, GF;Rios, JAP;Ruiz, JAG;Breedveld, RW;Hoogslag, PAM;Suryapranata, H;Oomen, A;Wiersma, JJ;Van Der Wal, RMA;Van Huysduynen-Monraats, PSH;Karalis, I;Verdel, GJE;Brueren, BRG;Troquay, RPT;Viergever, EP;Al-Windy, NYY;Bartels, GL;Cornel, JH;Hermans, WRM;Herrman, JPR;Bos, RJ;Groutars, RGEJ;Van Der Zwaan, CC;Kaplan, R;Ronner, E;Groenemeijer, BE;Bronzwaer, PNA;Liem, AAH;Rensing, BJWM;Bokern, MJJA;Nijmeijer, R;Hersbach, FMRJ;Willems, FF;Gosselink, ATM;Elliott, J;Wilkins, G;Fisher, R;Scott, D;Hart, H;Stewart, R;Harding, S;Ternouth, I;Fisher, N;Aitken, D;Anscombe, R;Tomala, T;Nygard, O;Sparby, JA;Andersen, K;Gullestad, L;Jortveit, J;Munk, PS;Hurtig, U;Ticona, JRC;Velasquez, JRD;Miguel, SAN;Perez, ESS;Chambilla, JMC;Ayala, CAC;Leon, RPC;Gonzales, RJV;Zuniga, JDH;Cosavalente, LAC;Mannucci, JEB;Navarro, NCL;Concha, YMR;Chavez, VER;Hernandez, HAA;Nunez, CAZ;Ferrolino, A;Sy, RAG;Tirador, L;Matiga, G;Coching, RM;Bernan, A;Rogelio, G;Morales, DD;Tan, E;Wlodarczak, A;Jaworska, K;Skonieczny, G;Pawlowicz, L;Wojewoda, P;Busz-Papiez, B;Bednarski, J;Goch, A;Staneta, P;Dulak, E;Saminski, K;Krasowski, W;Sudnik, W;Zurakowski, A;Skorski, M;Lysek, R;Miklaszewicz, B;Kubica, J;Lipko, JA;Kostarska-Srokosz, E;Piepiorka, M;Drzewiecka, A;Sciborski, R;Stasiewski, A;Blicharski, T;Bystryk, L;Szpajer, M;Korol, M;Czerski, T;Mirek-Bryniarska, E;Gniot, J;Lubinski, A;Gorny, J;Franek, E;Monteiro, P;Bastos, JM;Pereira, HH;Martins, D;Seixo, F;Mendonca, C;Botelho, A;Minescu, B;Istratoaie, O;Tesloianu, DN;Cristian, G;Podoleanu, CGC;Constantinescu, MCA;Bengus, CM;Militaru, C;Rosu, D;Parepa, IR;Matei, AV;Alexandru, TM;Shvarts, Y;Orlikova, O;Kobalava, Z;Barbarash, OL;Markov, V;Lyamina, N;Gordienko, A;Zrazhevsky, K;Vishnevsky, AY;Gurevich, V;Stryuk, R;Lomakin, NV;Bokarev, I;Shalaev, S;Khaisheva, L;Chizhov, P;Viktorova, I;Osokina, N;Akatova, E;Chumakova, G;Libov, I;Voevoda, MI;Tretyakova, TV;Baranov, E;Shustov, S;Yakushin, S;Gordeev, I;Khasanov, N;Reshetko, O;Sotnikova, T;Molchanova, O;Nikolaev, K;Gapon, L;Baranova, E;Shogenov, Z;Kosmachova, E;Karpov, Y;Povzun, A;Egorova, L;Tyrenko, VV;Ivanov, IG;Simic, D;Ivanovic, N;Davidovic, G;Tasic, N;Asanin, MR;Stojic, S;Apostolovic, SR;Ilic, S;Putnikovic, B;Stankovic, A;Arandjelovic, A;Radovanovic, S;Balinovac, J;Dincic, DV;Seferovic, P;Dodic, S;Dimkovic, S;Poh, KK;Ong, HY;Micko, K;Nociar, J;Pella, D;Fulop, P;Hranai, M;Palka, J;Mazur, J;Majercak, I;Dzupina, A;Fazekas, F;Gonsorcik, J;Bugan, V;Selecky, J;Kamensky, G;Strbova, J;Smik, R;Dukat, A;Zuran, I;Oklukar, J;Suligoj, NC;Cevc, M;Lipar, L;Cyster, HP;Ranjith, N;Corbett, C;Bayat, J;Makotoko, EM;Kapp, IE;Basson, MMD;Lottering, H;Van Zyl, LJ;Sebastian, PJ;Pillay, T;Saaiman, JA;Commerford, PJ;Cassimjee, S;Ebrahim, IO;Sarvan, M;Mynhardt, JH;Dalby, AJ;Reuter, H;Moodley, R;Vida, M;Fillat, ARC;Peris, VB;Jimenez, FF;Marin, F;Fernandez, JMC;Gil-Extremera, B;Diz, FW;Garcia-Dorado, D;Iniguez, A;Fernandez, JT;Gonzalez-Juanatey, JR;Portales, JF;Murillo, FC;Pericas, LM;Zamorano, JL;Martin, MD;Cortada, JB;Martin, JJA;Fernandez, JRD;Fernandez, JFD;Lledo, JAG;Sales, JC;Rodriguez, JB;Tragant, GG;Benedicto, A;Gonzalez-Juanatey, C;Potau, MC;Perez, IP;De La Tassa, CM;Rincon, PLO;Recena, JB;Escudier, JM;Constantine, G;Haniffa, R;Tissera, N;Amarasekera, S;Fernando, N;Jayawardena, J;Santharaj, W;Ekanayaka, R;Mendis, S;Senaratne, V;Mayurathan, G;Sirisena, T;Rajapaksha, A;Herath, JI;Amarasena, N;Berglund, S;Rasmanis, G;Hagstrom, E;Witt, N;Mourtzinis, G;Nicol, P;Hansen, O;Romeo, S;Jensen, SA;Torstensson, I;Jensen, SA;Ahremark, U;Sundelin, T;Moccetti, T;Muller, C;Mach, F;Binder, R;Chiang, CE;Tsai, WC;Ueng, KC;Lai, WT;Liu, ME;Hwang, JJ;Yin, WH;Hsieh, IC;Lin, WH;Kuo, JY;Huang, TY;Fang, 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    Keywords: acute coronary syndromes;alirocumab;low-density lipoprotein cholesterol;major adverse cardiovascular events;proprotein convertase subtilisin/kexin type 9 inhibition
    Date: 2020
    Issue Date: 2022-08-09T08:10:42Z (UTC)
    Publisher: ELSEVIER SCIENCE INC
    ISSN: 0735-1097
    Abstract: BACKGROUND Lipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C). OBJECTIVES A pre-specified analysis of the placebo-controlled ODYSSEY Outcomes trial in patients with recent acute coronary syndrome (ACS) determined whether alirocumab-induced changes in lipoprotein(a) and LDL-C independently predicted major adverse cardiovascular events (MACE). METHODS One to 12 months after ACS, 18,924 patients on high-intensity statin therapy were randomized to alirocumab or placebo and followed for 2.8 years (median). Lipoprotein(a) was measured at randomization and 4 and 12 months thereafter. The primary MACE outcome was coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina. RESULTS Baseline lipoprotein(a) levels (median: 21.2 mg/dl; interquartile range [IQR]: 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE. Alirocumab reduced lipoprotein(a) by 5.0 mg/dl (IQR: 0 to 13.5 mg/dl), corrected LDL-C by 51.1 mg/dl (IQR: 33.7 to 67.2 mg/dl), and reduced the risk of MACE (hazard ratio [HR]: 0.85; 95% confidence interval [CI]: 0.78 to 0.93). Alirocumab-induced reductions of lipoprotein(a) and corrected LDL-C independently predicted lower risk of MACE, after adjustment for baseline concentrations of both lipoproteins and demographic and clinical characteristics. A 1-mg/dl reduction in lipoprotein(a) with alirocumab was associated with a HR of 0.994 (95% CI: 0.990 to 0.999; p = 0.0081). CONCLUSIONS Baseline lipoprotein(a) and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS. Lipoprotein(a) lowering by alirocumab is an independent contributor to MACE reduction, which suggests that lipoprotein(a) should be an independent treatment target after ACS. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
    URI: http://dx.doi.org/10.1016/j.jacc.2019.10.057
    https://www.webofscience.com/wos/woscc/full-record/WOS:000506877300001
    https://ir.csmu.edu.tw:8080/handle/310902500/24946
    Relation: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY ,2020 ,v75 ,issue 2 ,p133-144
    Appears in Collections:[中山醫學大學研究成果] 期刊論文

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