Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

doi:10.1016/j.ygeno.2019.07.008

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24944

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24944

Title:	Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
Authors:	Wong, JYY;Zhang, H;Hsiung, CA;Shiraishi, K;Yu, K;Matsuo, K;Wong, MP;Hong, YC;Wang, JC;Seow, WJ;Wang, ZM;Song, MS;Kim, HN;Chang, IS;Chatterjee, N;Hu, W;Wu, C;Mitsudomi, T;Zheng, W;Kim, JH;Seow, A;Caporaso, NE;Shin, MH;Chung, LP;An, SJ;Wang, P;Yang, Y;Zheng, H;Yatabe, Y;Zhang, XC;Kim, YT;Cai, QY;Yin, ZH;Kim, YC;Bassig, BA;Chang, J;Ho, JCN;Ji, BT;Daigo, Y;Ito, H;Momozawa, Y;Ashikawa, K;Kamatani, Y;Honda, T;Hosgood, HD;Sakamoto, H;Kunitoh, H;Tsuta, K;Watanabe, SI;Kubo, M;Miyagi, Y;Nakayama, H;Matsumoto, S;Tsuboi, M;Goto, K;Shi, JX;Song, L;Hua, X;Takahashi, A;Goto, A;Minamiya, Y;Shimizu, K;Tanaka, K;Wei, F;Matsuda, F;Su, J;Kim, YH;Oh, IJ;Song, FJ;Su, WC;Chen, YM;Chang, GC;Chen, KY;Huang, MS;Chien, LH;Xiang, YB;Park, JY;Kweon, SS;Chen, CJ;Lee, KM;Blechter, B;Li, HX;Gao, YT;Qian, BY;Lu, DR;Liu, JJ;Jeon, HS;Hsiao, CF;Sung, JS;Tsai, YH;Jung, YJ;Guo, H;Hu, ZB;Wang, WC;Chung, CC;Burdett, L;Yeager, M;Hutchinson, A;Berndt, SI;Wu, W;Pang, H;Li, YQ;Choi, JE;Park, KH;Sung, SW;Liu, L;Kang, CH;Zhu, M;Chen, CH;Yang, TY;Xu, J;Guan, P;Tan, W;Wang, CL;Hsin, M;Sit, KY;Chen, Y;Choi, YY;Hung, JY;Kim, JS;Il Yoon, H;Lin, CC;Park, IK;Xu, P;Wang, Y;He, Q;Perng, RP;Chen, CY;Vermeulen, R;Wu, JJ;Lim, WY;Chen, KC;Li, YJ;Li, JH;Chen, HY;Yu, CJ;Jin, L;Chen, TY;Jiang, SS;Liu, J;Yamaji, T;Hicks, B;Wyatt, K;Li, SA;Dai, JC;Ma, HX;Jin, GF;Song, B;Wang, ZH;Cheng, SS;Li, XL;Ren, YW;Cui, P;Iwasaki, M;Shimazu, T;Tsugane, S;Zhu, JJ;Yang, KY;Jiang, GN;Fei, K;Wu, GP;Lin, HC;Chen, HL;Fang, YH;Tsai, FY;Hsieh, WS;Yu, JM;Stevens, VL;Laird-Offringa, IA;Marconett, CN;Rieswijk, L;Chao, A;Yang, PC;Shu, XO;Wu, T;Wu, YL;Lin, DX;Chen, KX;Zhou, BS;Huang, YC;Kohno, T;Shen, H;Chanock, SJ;Rothman, N;Lan, Q
Keywords:	Tuberculosis;Lung cancer;Lung adenocarcinoma;Mendelian randomization;Pathway analysis
Date:	2020
Issue Date:	2022-08-09T08:10:37Z (UTC)
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN:	0888-7543
Abstract:	We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
URI:	http://dx.doi.org/10.1016/j.ygeno.2019.07.008 https://www.webofscience.com/wos/woscc/full-record/WOS:000514071600020 https://ir.csmu.edu.tw:8080/handle/310902500/24944
Relation:	GENOMICS ,2020 ,v112 ,issue 2 ,p1223-1232
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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