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https://ir.csmu.edu.tw:8080/ir/handle/310902500/24934
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Title: | Predicting Lung Cancer Occurrence in Never-Smoking Females in Asia: TNSF-SQ, a Prediction Model |
Authors: | Chien, LH;Chen, CH;Chen, TY;Chang, GC;Tsai, YH;Hsiao, CF;Chen, KY;Su, WC;Wang, WC;Huang, MS;Chen, YM;Chen, CY;Liang, SK;Chen, CY;Wang, CL;Lee, MH;Chung, RH;Tsai, FY;Hu, JW;Katki, HA;Chatterjee, N;Chanock, SJ;Rothman, N;Lan, Q;Yang, PC;Chen, CJ;Chang, IS;Hsiung, CA |
Date: | 2020 |
Issue Date: | 2022-08-09T08:10:26Z (UTC)
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Publisher: | AMER ASSOC CANCER RESEARCH |
ISSN: | 1055-9965 |
Abstract: | Background: High disease burden suggests the desirability to identify high-risk Asian never-smoking females (NSF) who may benefit from low-dose CT (LDCT) screening. In North America, one is eligible for LDCT screening if one satisfies the U.S. Preventive Services Task Force (USPSTF) criteria or has model-estimated 6-year risk greater than 0.0151. According to two U.S. reports, only 36.6% female patients with lung cancer met the USPSTF criteria, while 38% of the ever-smokers ages 55 to 74 years met the USPSTF criteria. Methods: Using data on NSFs in the Taiwan Genetic Epidemiology Study of Lung Adenocarcinoma and the Taiwan Biobank before August 2016, we formed an age-matched case-control study consisting of 1,748 patients with lung cancer and 6,535 controls. Using these and an estimated age-specific lung cancer 6-year incidence rate among Taiwanese NSFs, we developed the Taiwanese NSF Lung Cancer Risk Models using genetic information and simplified questionnaire (TNSF-SQ). Performance evaluation was based on the newer independent datasets: Taiwan Lung Cancer Pharmacogenomics Study (LCPG) and Taiwan Biobank data after August 2016 (TWB2). Results: The AUC based on the NSFs ages 55 to 70 years in LCPG and TWB2 was 0.714 [95% confidence intervals (CI), 0.660-0.768]. For women in TWB2 ages 55 to 70 years, 3.94% (95% CI, 2.95-5.13) had risk higher than 0.0151. For women in LCPG ages 55 to 74 years, 27.03% (95% CI, 19.04-36.28) had risk higher than 0.0151. Conclusions: TNSF-SQ demonstrated good discriminative power. The ability to identify 27.03% of high-risk Asian NSFs ages 55 to 74 years deserves attention. Impact: TNSF-SQ seems potentially useful in selecting Asian NSFs for LDCT screening. |
URI: | http://dx.doi.org/10.1158/1055-9965.EPI-19-1221 https://www.webofscience.com/wos/woscc/full-record/WOS:000521285500022 https://ir.csmu.edu.tw:8080/handle/310902500/24934 |
Relation: | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION ,2020 ,v29 ,issue 2 ,p452-459 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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