Endoscopic management of strictures in patients with Crohn's disease - A multi-center experience in Taiwan

doi:10.1016/j.jfma.2019.12.005

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24931

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24931

Title:	Endoscopic management of strictures in patients with Crohn's disease - A multi-center experience in Taiwan
Authors:	Chang, CW;Tu, CH;Chou, JW;Huang, TY;Hsu, WH;Wang, YP;Chen, CC;Chung, CS;Lin, CP;Lin, WC;Tai, CM;Wang, HY;Chen, MJ
Keywords:	Endoscopy;Stricture;Crohn's disease
Date:	2020
Issue Date:	2022-08-09T08:10:23Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	0929-6646
Abstract:	Background/Purpose: Inflammatory bowel disease (IBD) is a chronic gastrointestinal (GI) disorder that causes relapsing inflammation and severe mucosal damage in the intestine. Crohn's disease (CD)-related stricturing complications are a major cause of surgery, disability, and reduced quality of life. Endoscopic balloon dilation (EBD) has been shown to reliably delay or prevent surgery in patients with stricturing CD. However, cases of EBD performed for stricture in CD in Taiwan are rare. In this study, we want to evaluate the experiences regarding EBD for stricturing CD in Taiwan. Methods: We conducted a retrospective analysis of 9 medical centers in Taiwan. Patients with CD-related strictures who were treated with EBD were included and analyzed. Results: In nine medical centers, a total of 26 CD patients (19 male, 7 female, mean disease duration 75.4 +/- 65.2 months) underwent 42 EBD procedures during the study period. Among the subjects, an 83.3% (35/42) EBD success rate was seen, but 26.9% (7/26) patients underwent surgery after ineffective EBD. In the surgery group, the the small bowel strictures was high compared with the non-surgery group (p = 0.01). There were no significant differences in disease phenotype, disease duration or history of fistulizing disease. In the surgery group, immunosuppressant use was high, and 5-aminosalicylic acid (5-ASA) use was low compared with the non-surgery group. After EBD, the physicians tended to change the drugs, especially increasing the use of biologic agents. Conclusion: EBD is a safe and effective procedure for CD-related stricture, with a 83.3% success rate in Taiwan. Copyright (C) 2019, Formosan Medical Association. Published by Elsevier Taiwan LLC.
URI:	http://dx.doi.org/10.1016/j.jfma.2019.12.005 https://www.webofscience.com/wos/woscc/full-record/WOS:000574758100006 https://ir.csmu.edu.tw:8080/handle/310902500/24931
Relation:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION ,2020 ,v119 ,issue 10 ,p1500-1505
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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