New Use for Old Drugs: The Protective Effect of Risperidone on Colorectal Cancer

doi:10.3390/cancers12061560

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24912

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24912

Title:	New Use for Old Drugs: The Protective Effect of Risperidone on Colorectal Cancer
Authors:	Chen, VCH;Hsieh, YH;Lin, TC;Lu, ML;Liao, YT;Yang, YH;Hsu, TC;Stewart, R;Weng, JC;Lee, MJ;Chiu, WC;Tzang, BS
Keywords:	antipsychotics;colorectal cancer;Taiwan National Health Insurance;risperidone;SW480
Date:	2020
Issue Date:	2022-08-09T08:10:01Z (UTC)
Publisher:	MDPI
Abstract:	(1) Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving population-based, cell, and animal studies to investigate the effects of risperidone, a type of second-generation antipsychotic (SGA) drug, on colorectal cancer. (2) Methods: We used data from Taiwan's National Health Insurance Research Database between 1997 and 2013 to compare 101,989 patients with colorectal cancer and 101,989 controls. Conditional logistic regression analyses were used to explore the association between SGA exposure and the risk of colorectal cancer. The following bench studies were performed to evaluate the findings of the population-based study. (3) Results: We found that SGAs had been less commonly used in colorectal cancer patients than in controls. The colorectal cancer risk was reduced with an increase in the cumulative defined daily dose (cDDD) of SGAs. The adjusted odds ratio of antipsychotic use for cDDD days was 0.32 (95% CI: 0.25-0.42). Risperidone exhibited the most prominent tumor inhibition effect in a cell screen study. Bench data revealed that risperidone significantly induced apoptosis and elevated intracellular ROS in human SW480 cells and suppressed the proliferation of the xenografted SW480 tumor in nude mice. (4) Conclusion: This triple-model study demonstrates the association between risperidone usage and a lower risk of colorectal cancer.
URI:	http://dx.doi.org/10.3390/cancers12061560 https://www.webofscience.com/wos/woscc/full-record/WOS:000549260400001 https://ir.csmu.edu.tw:8080/handle/310902500/24912
Relation:	CANCERS ,2020 ,v12 ,issue 6
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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