中山醫學大學機構典藏 CSMUIR:Item 310902500/24893
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    题名: Adenovirus infection and subsequent risk of Kawasaki disease: A population-based cohort study
    作者: Huang, SH;Chen, CY;Weng, KP;Chien, KJ;Hung, YM;Hsieh, KS;Lin, CC;Cheng, MF;Lin, CL;Wei, JCC
    关键词: Adenovirus;Cohort study;Kawasaki disease
    日期: 2020
    上传时间: 2022-08-09T08:09:42Z (UTC)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    ISSN: 1726-4901
    摘要: Background: The relationship between adenovirus infection and Kawasaki disease (KD) is unclear. The purpose of this study was to determine the relationship between adenovirus infection and KD using a cohort study in Taiwan. Methods: We used Taiwan National Health Insurance data (from 2000 to 2008) to conduct a population-based cohort study, analyzing children that was under 18 years of age. In total, 5280 children had adenovirus infection, and 5280 children without adenovirus infection were matched and followed up. Subsequent KD was the major outcome event. The Cox proportional hazards model was used to estimate the hazard ratio (HR) with 95% confidence intervals (CIs) of developing KD associated with adenovirus infection. Results: There was a significantly higher cumulative incidence of KD in the adenovirus-infected cohort than that in the control cohort (log-rank test, p < 0.001). In the adenovirus-infected cohort, overall incidence of KD was 5.29 times higher than that of the control cohort (adjusted HR 5.29, 95% CI: 2.48-11.3). Increased KD risk was associated with previous adenovirus infection in children aged 3-5 years, in female patients, in those with a low urbanization level, and in those with allergies. Conclusion: An association between previous adenovirus infection and KD was identified in Taiwanese children, but other potential risk factors were not fully analyzed. The relationship between infection and KD requires further study.
    URI: http://dx.doi.org/10.1097/JCMA.0000000000000266
    https://www.webofscience.com/wos/woscc/full-record/WOS:000524756800016
    https://ir.csmu.edu.tw:8080/handle/310902500/24893
    關聯: JOURNAL OF THE CHINESE MEDICAL ASSOCIATION ,2020 ,v83 ,issue 3 ,p302-306
    显示于类别:[中山醫學大學研究成果] 期刊論文

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