Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats

doi:10.1152/japplphysiol.00844.2019

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24886

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24886

Title:	Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats
Authors:	Lin, YY;Hong, Y;Zhou, MC;Huang, HL;Shyu, WC;Chen, JS;Ting, H;Cheng, YJ;Yang, AL;Lee, SD
Keywords:	estrogen deficiency;inflammation;myocardial fibrosis;treadmill training
Date:	2020
Issue Date:	2022-08-09T08:09:36Z (UTC)
Publisher:	AMER PHYSIOLOGICAL SOC
ISSN:	8750-7587
Abstract:	This study investigated the effects of exercise training on cardiac inflammatory and cardiac fibrotic pathways in female spontaneously hypertensive rats (SHR), which were divided into a sham-operated sedentary hypertensive group (SHR-S), a sedentary hypertensive ovariectomized group (SHR-O), or a hypertensive ovariectomized group with treadmill exercise training (SHR-OT; 60 min/day, 5 days/wk) for 8 wk. Normotensive female Wistar-Kyoto rats (WKY) served as controls. SOD and catalase (CAT) activities were significantly increased in the SHR-OT group, when compared with the SHR-S or SHR-O groups. The protein levels of estrogen receptor (ER)-alpha and ER-beta became decreased in the SHR-O group, when compared with the WKY or SHR-S groups, but were not changed in the SHR-OT group. The protein level of the angiotensin II type I receptor (AT(1)R) was increased in the SHR-S group but did not further change in the SHR-O group, whereas it was decreased in the SHR-OT group. The inflammatory-related protein levels of TNF-alpha, p-NF-kappa B, cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and IL-6. as well as the fibrotic-related protein levels of transforming growth factor-beta (TGF-beta), p-Smad2/3, connective tissue growth factor (CTGF), tissue-type plasminogen activator (tPA), matrix metalloproteinase (MMP)-9. and collagen I were increased in the SHR-S group and increased further in the SHR-O group. whereas they were decreased in the SHR-OT group. The coexistence of hypertension and ovariectomy additively increased cardiac inflammatory and fibrotic pathways partially through hypertension-enhanced AT(1)R and ovariectomy-depressed estrogen receptors. Exercise training appeared to suppress hypertensive ovariectomized heart-induced inflammatory and fibrotic pathways possibly through decreasing AT(1)R but not through estrogen receptors. NEW & NOTEWORTHY The coexistence of hypertension and ovariectomy appeared to increase cardiac inflammatory and fibrotic pathways likely through hypertension-enhanced angiotensin II type I receptor and ovariectomy-depressed estrogen receptors. Exercise training on a treadmill could prevent hypertensive ovariectomized heart-induced cardiac inflammation and fibrosis via an inflammatory pathway [TNF-alpha, p-IKK-alpha/beta, p-NF-kappa B, cyclooxygenase 2 (COX-2), iNOS. and IL-6] and fibrotic pathway [transforming growth factor-beta (TGF-beta), p-Smad2/3, connective tissue growth factor (CTGF). tissue-type plasminogen activator (tPA), matrix metalloproteinase (MMP)-9, and collagen I] possibly through decreasing angiotensin II type I receptor but not through estrogen receptors.
URI:	http://dx.doi.org/10.1152/japplphysiol.00844.2019 https://www.webofscience.com/wos/woscc/full-record/WOS:000528322200032 https://ir.csmu.edu.tw:8080/handle/310902500/24886
Relation:	JOURNAL OF APPLIED PHYSIOLOGY ,2020 ,v128 ,issue 4 ,p1033-1043
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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