Loading...
|
Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/24881
|
Title: | Vagus nerve stimulation for patients with refractory epilepsy: Demographic features and neuropsychological outcomes of the VNS Taiwan child neurology society database |
Authors: | Tsai, JD;Yang, RC;Chang, MY;Fan, HC;Hung, KL |
Keywords: | Taiwan child neurology society (TCNS);Vagus nerve stimulation;Seizures frequency reduction;Parental stress index (PSI);Refractory epilepsy (RE) |
Date: | 2020 |
Issue Date: | 2022-08-09T08:09:30Z (UTC)
|
Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
ISSN: | 1525-5050 |
Abstract: | Objectives: Vagus nerve stimulation (VNS) is an established adjunctive therapy for medically refractory epilepsy, which is commonly associated with cognitive impairment especially in children in whom seizures may disrupt development that is essential to their intellectual and social maturation. The Taiwan Child Neurology Society intends to expand the use of VHS by reporting the experience in a nationwide population, displaying the demographic features and neuropsychological outcomes of VNS. Methods: The enrollment induded 105 patients of all ages and seizure types who underwent VNS implantation for refractory epilepsy. Basic data included etiology, past history, seizure phenotypes, and epileptiform syndromes. For efficacy analysis, seizure frequencies were recorded at the baseline and at 3, 12, 24, and 36 months after VNS implantation. For psychological assessment, intelligence quotients (IQ) and Parental Stress Index (PSI) scores were evaluated before and after the VNS. Results: During the study period, 95 patients with VNS had followed seizure frequency, lQand PSI recording. After implantation, there was a decreased frequency at 3 (P < .001), 12 (P < .001), 24 (A= .010), and 36 (P < .01) months. After implantation, the reduction rate (0-50%) of seizure frequency ranged around 26.1-36.1% from 3 to 36 months. For PSI scores, the VNS significantly improved the PSI- total score (P = .001) and PSI-parent domain (P = .001) but not the PSI-children domain (P = .052). No significant improvement in the IQ test performance was observed. Conclusions: This prospective nationwide database of VNS in Taiwan indicates long-term efficacy of VNS therapy, which has achieved a trend of seizure frequency reduction over a period of up to 36 months. It also shows the trend of decreased parental stress after VNS implantation. (C) 2020 Elsevier Inc. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.yebeh.2020.107186 https://www.webofscience.com/wos/woscc/full-record/WOS:000577327900023 https://ir.csmu.edu.tw:8080/handle/310902500/24881 |
Relation: | EPILEPSY & BEHAVIOR ,2020 ,v111 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
|
Files in This Item:
File |
Description |
Size | Format | |
index.html | | 0Kb | HTML | 191 | View/Open |
|
All items in CSMUIR are protected by copyright, with all rights reserved.
|