中山醫學大學機構典藏 CSMUIR:Item 310902500/24876
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17939/22958 (78%)
造访人次 : 7390183      在线人数 : 125
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24876


    题名: Antiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non-Small Cell Lung Cancer through Inactivating ERK/CTSD Signalling Pathways
    作者: Liu, CM;Shen, HT;Lin, YA;Yu, YL;Chen, YS;Liu, CJ;Hsieh, YH
    关键词: Praeruptorin C;non-small cell lung cancer;proliferation;invasion;cathepsin D
    日期: 2020
    上传时间: 2022-08-09T08:09:26Z (UTC)
    出版者: MDPI
    摘要: Praeruptorin C (PC) reportedly has beneficial effects in terms of antiinflammation, antihypertension, and antiplatelet aggregation, and it potentially has anticancer activity. However, the effect of PC on human non-small cell lung cancer (NSCLC) is largely unknown. Compared with the effects of praeruptorin A and praeruptorin B, we observed that PC significantly suppressed cell proliferation, colony formation, wound closure, and migration and invasion of NSCLC cells. It induced cell cycle arrest in the G0/G1 phase, downregulated cyclin D1 protein, and upregulated p21 protein. PC also significantly reduced the expression of cathepsin D (CTSD). In addition, the phosphorylation/activation of the ERK1/2 signalling pathway was significantly suppressed in PC-treated NSCLC cells. Cotreatment with PC and U0126 synergistically inhibited CTSD expression, cell migration, and cell invasion, which suggests that the ERK1/2 signalling pathway is involved in the downregulation of CTSD expression and invasion activity of NSCLC cells by PC. These findings are the first to demonstrate the inhibitory effects of PC in NSCLC progression. Therefore, PC may represent a novel strategy for treating NSCLC.
    URI: http://dx.doi.org/10.3390/molecules25071625
    https://www.webofscience.com/wos/woscc/full-record/WOS:000531833400150
    https://ir.csmu.edu.tw:8080/handle/310902500/24876
    關聯: MOLECULES ,2020 ,v25 ,issue 7
    显示于类别:[中山醫學大學研究成果] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML162检视/开启


    SFX Query

    在CSMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈