Antiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non-Small Cell Lung Cancer through Inactivating ERK/CTSD Signalling Pathways

doi:10.3390/molecules25071625

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24876

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24876

Title:	Antiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non-Small Cell Lung Cancer through Inactivating ERK/CTSD Signalling Pathways
Authors:	Liu, CM;Shen, HT;Lin, YA;Yu, YL;Chen, YS;Liu, CJ;Hsieh, YH
Keywords:	Praeruptorin C;non-small cell lung cancer;proliferation;invasion;cathepsin D
Date:	2020
Issue Date:	2022-08-09T08:09:26Z (UTC)
Publisher:	MDPI
Abstract:	Praeruptorin C (PC) reportedly has beneficial effects in terms of antiinflammation, antihypertension, and antiplatelet aggregation, and it potentially has anticancer activity. However, the effect of PC on human non-small cell lung cancer (NSCLC) is largely unknown. Compared with the effects of praeruptorin A and praeruptorin B, we observed that PC significantly suppressed cell proliferation, colony formation, wound closure, and migration and invasion of NSCLC cells. It induced cell cycle arrest in the G0/G1 phase, downregulated cyclin D1 protein, and upregulated p21 protein. PC also significantly reduced the expression of cathepsin D (CTSD). In addition, the phosphorylation/activation of the ERK1/2 signalling pathway was significantly suppressed in PC-treated NSCLC cells. Cotreatment with PC and U0126 synergistically inhibited CTSD expression, cell migration, and cell invasion, which suggests that the ERK1/2 signalling pathway is involved in the downregulation of CTSD expression and invasion activity of NSCLC cells by PC. These findings are the first to demonstrate the inhibitory effects of PC in NSCLC progression. Therefore, PC may represent a novel strategy for treating NSCLC.
URI:	http://dx.doi.org/10.3390/molecules25071625 https://www.webofscience.com/wos/woscc/full-record/WOS:000531833400150 https://ir.csmu.edu.tw:8080/handle/310902500/24876
Relation:	MOLECULES ,2020 ,v25 ,issue 7
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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