Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome

doi:10.1007/s11655-020-3216-2

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24871

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24871

Title:	Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome
Authors:	Chen, YH;Chen, WC;Tsai, KS;Liu, PL;Tsai, MY;Lin, TC;Yu, SC;Chen, HY
Keywords:	frankincense;myrrha;acute interstitial cystitis;painful bladder syndrome;cell junction-associated Protein
Date:	2020
Issue Date:	2022-08-09T08:09:21Z (UTC)
Publisher:	SPRINGER
ISSN:	1672-0415
Abstract:	Objective To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome (IC/PBS). Methods The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial cells (HUCs) were assessed in vitro. In the animal study, 48 virgin female rats were randomized into 4 groups (12 in each group): (1) control group (saline-injected control); (2) cyclophosphamide (CYP) group (intraperitoneal injected 150 mg/kg CYP); (3) CYP + pentosan polysulfate sodium group (orally received 50 mg/kg pentosan polysulfate sodium); and (4) CYP + frankincense and myrrha group [orally received frankincense (200 mg/kg) and myrrha (200 mg/kg)]. Rats orally received pentosan polysulfate sodium or frankincense and myrrha on day 1, 2, and 3. The experiments were performed on day 4. Pain and cystometry assessment behavior test were performed. Voiding interval values were assessed in rats under anesthesia. Finally, immunohistochemistry and Western blot were used to confifirm the location and level, respectively, of cell junction-associated protein zonula occludens-2 (ZO-2) expression. Results Low dose frankincense and myrrha increased cell proliferation and migration in HUCs compared with control (P<0.05). Rats with acute IC/PBS rats exhibited lower voiding interval values, pain tolerance, and ZO-2 expression (P<0.05). Voiding interval values and pain tolerance were higher in the frankincense and myrrha group than CYP group (P<0.05). ZO-2 expression in the bladder was increased in the CYP + pentosan polysulfate and frankincense + myrrha groups compared with the CYP-induced acute IC/PBS group (P<0.05). Conclusion frankincense and myrrha modulate urothelial wound healing, which ameliorates typical features of acute IC/PBS in rats.
URI:	http://dx.doi.org/10.1007/s11655-020-3216-2 https://www.webofscience.com/wos/woscc/full-record/WOS:000525169800001 https://ir.csmu.edu.tw:8080/handle/310902500/24871
Relation:	CHINESE JOURNAL OF INTEGRATIVE MEDICINE ,2020 ,v26 ,issue 7 ,p519-526
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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