The Association Between Parkinson's Disease and Attention-Deficit Hyperactivity Disorder

doi:10.1177/0963689720947416

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24851

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24851

Title:	The Association Between Parkinson's Disease and Attention-Deficit Hyperactivity Disorder
Authors:	Fan, HC;Chang, YK;Tsai, JD;Chiang, KL;Shih, JH;Yeh, KY;Ma, KH;Li, IH
Keywords:	Parkinson's disease;attention-deficit hyperactivity disorder;Longitudinal Health Insurance Database 2000;6-hydroxydopamine
Date:	2020
Issue Date:	2022-08-09T08:09:01Z (UTC)
Publisher:	SAGE PUBLICATIONS INC
ISSN:	0963-6897
Abstract:	While Parkinson's disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes. In order to investigate that hypothesis, this study used claims data from Taiwan's Longitudinal Health Insurance Database 2000 to provide the significant nationwide population-based evidence of an increased risk of PD among ADHD patients, and the connection between the two conditions was not the result of other comorbidities. Moreover, this study showed that the patients with PD were 2.8 times more likely to have a prior ADHD diagnosis compared with those without a prior history of ADHD. Furthermore, an animal model of ADHD was generated by neonatally injecting rats with 6-hydroxydopamine (6-OHDA). These rats were subjected to behavior tests and the 99mTc-TRODAT-1 brain imaging at the juvenile stage. Compared to control group rats, the 6-OHDA rats showed a significantly reduced specific uptake ratio in the striatum, indicating an underlying PD-linked pathology in the brains of these ADHD phenotype-expressing rats. Overall, these results support that ADHD shares a number of anatomical and neurochemical changes with PD. As such, improved knowledge of the neurochemical mechanisms underlying ADHD could result in improved treatments for various debilitating neurological disorders, including PD.
URI:	http://dx.doi.org/10.1177/0963689720947416 https://www.webofscience.com/wos/woscc/full-record/WOS:000606584100001 https://ir.csmu.edu.tw:8080/handle/310902500/24851
Relation:	CELL TRANSPLANTATION ,2020 ,v29
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	234	View/Open

Loading...