Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study

doi:10.3390/diagnostics10040201

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24848

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24848

Title:	Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study
Authors:	Chen, CS;Li, JR;Wang, SS;Yang, CK;Cheng, CL;Yang, CR;Ou, YC;Ho, HC;Lin, CY;Hung, SC;Chen, CC;Wang, SC;Chiu, KY;Yang, SF
Keywords:	urinary bladder;recurrence;nephroureterectomy;upper tract urothelial carcinoma;tumor multifocality
Date:	2020
Issue Date:	2022-08-09T08:08:58Z (UTC)
Publisher:	MDPI
Abstract:	The purpose of this study was to identify the significant risk factors of urinary bladder recurrence (UBR) after nephroureterectomy (NUx) in patients with upper tract urothelial carcinoma (UTUC). A total of 550 patients diagnosed with UTUC between January 2001 and December 2015 were included in this retrospective study. The median age of our patients was 68 (range 24-93) and the median follow-up time after NUx was 40.3 months (range 8-191). The most important censored point of this study was the first episode of UBR. Of the 550 patients, UBR occurred in 164 patients (29.8%). One hundred and forty-two (86.6%) patients with UBR were identified within two years after NUx for UTUC, with the median time interval between NUx and UBR being 8.4 months (range 3-59.8). Through univariate analysis, the positive surgical margin (p = 0.049) and tumor multifocality (p = 0.024) were both significant prognostic factors for UBR-free survival after NUx in patients with UTUC. However, only tumor multifocality (p = 0.037) remained a significant prognostic factor by multivariate analysis. In conclusion, tumor multifocality is a significant risk factor of UBR after nephroureterectomy in patients with upper tract urothelial carcinoma.
URI:	http://dx.doi.org/10.3390/diagnostics10040201 https://www.webofscience.com/wos/woscc/full-record/WOS:000534251000034 https://ir.csmu.edu.tw:8080/handle/310902500/24848
Relation:	DIAGNOSTICS ,2020 ,v10 ,issue 4
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	181	View/Open

Loading...