中山醫學大學機構典藏 CSMUIR:Item 310902500/24846
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    题名: Impact of Gene Polymorphisms in GAS5 on Urothelial Cell Carcinoma Development and Clinical Characteristics
    作者: Weng, WC;Chen, CJ;Chen, PN;Wang, SS;Hsieh, MJ;Yang, SF
    关键词: urothelial cell carcinoma;growth arrest-specific 5;polymorphism;susceptibility
    日期: 2020
    上传时间: 2022-08-09T08:08:56Z (UTC)
    出版者: MDPI
    摘要: Urothelial cell carcinoma (UCC) is the commonest malignant tumor of the urinary tract and the second most common kidney cancer malignancy. Growth arrest-specific 5 (GAS5), a long noncoding RNA, is encoded by the GAS5 gene and plays a critical role in cellular growth arrest and apoptosis. In the current study, two single nucleotide polymorphisms (SNPs) in the GAS5 gene, rs145204276 and rs55829688, were selected to investigate correlations between these single SNPs and susceptibility to UCC. A total of 430 UCC cases and 860 ethnically matched healthy controls were included. SNP rs145204276 and SNP rs55829688 were determined using a TaqMan genotyping assay. Logistic regression models demonstrated that female patients with UCC carrying the rs145204276 GAS5 Ins/Del or Del/Del genotype had a 3.037-fold higher risk of larger tumor status (95% confidence interval 1.259-7.324) than did rs145204276 wild type (Ins/Ins) carriers (p = 0.011). The Cancer Genome Atlas validation cohort analysis demonstrated that the expression of GAS5 in female patients with bladder urothelial carcinoma (BLCA) with larger tumor size was much lower than that in patients with a smaller tumor size (p = 0.041). Kaplan-Meier curve analysis and the log-rank test revealed that female patients with BLCA and lower GAS5 expression had poorer overall survival than those with higher GAS5 expression. In conclusion, genetic variations in GAS5 rs145204276 may serve as a critical predictor of the clinical status of female patients with UCC.
    URI: http://dx.doi.org/10.3390/diagnostics10050260
    https://www.webofscience.com/wos/woscc/full-record/WOS:000541022500004
    https://ir.csmu.edu.tw:8080/handle/310902500/24846
    關聯: DIAGNOSTICS ,2020 ,v10 ,issue 5
    显示于类别:[中山醫學大學研究成果] 期刊論文

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