中山醫學大學機構典藏 CSMUIR:Item 310902500/24813
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    题名: Persons with type 2 diabetes and high insulin persistence were associated with a lower risk of mortality: A nationwide retrospective cohort study
    作者: Yen, FS;Wei, JCC;Liu, JS;Hsu, CC;Hwu, CM
    关键词: All-cause mortality;Cardiovascular disease;Insulin persistence
    日期: 2021
    上传时间: 2022-08-09T08:08:24Z (UTC)
    出版者: WILEY
    ISSN: 2040-1116
    摘要: Aims/Introduction Studies assessing the long-term outcomes of insulin persistence are scant. We compared the risk of all-cause mortality among patients with different degrees of insulin persistence. Materials and Methods In total, 293,210 patients with type 2 diabetes mellitus undergoing insulin therapy were enrolled during 2002-2014. Insulin persistence was defined as continual insulin treatment without a 90-day gap of discontinuation in the 2-year observation period. Mortality rates were compared between 111,220 patients with >= 90% insulin persistence and 111,220 matched patients with During the mean 5.37-year follow-up period, the mortality rates were 58.26 and 73.21 per 1,000 person-years for patients with >= 90% and <90% of insulin persistence. The adjusted hazard ratio for mortality was 0.80 (95% confidence interval 0.79-0.81,P < 0.001). Patients with high insulin persistence had significantly lower risks than did those with low insulin persistence of death due to hypertension, diabetes, cardiovascular disease, liver disease, kidney disease, respiratory disease, sepsis and cancer. Conclusions This study showed that patients with >= 90% insulin persistence were associated with lower risks of all-cause mortality than did patients with <90% insulin persistence.
    URI: http://dx.doi.org/10.1111/jdi.13330
    https://www.webofscience.com/wos/woscc/full-record/WOS:000552147700001
    https://ir.csmu.edu.tw:8080/handle/310902500/24813
    關聯: JOURNAL OF DIABETES INVESTIGATION ,2021 ,v12 ,issue 2 ,p146-154
    显示于类别:[中山醫學大學研究成果] 期刊論文

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