Persons with type 2 diabetes and high insulin persistence were associated with a lower risk of mortality: A nationwide retrospective cohort study

doi:10.1111/jdi.13330

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24813

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24813

Title:	Persons with type 2 diabetes and high insulin persistence were associated with a lower risk of mortality: A nationwide retrospective cohort study
Authors:	Yen, FS;Wei, JCC;Liu, JS;Hsu, CC;Hwu, CM
Keywords:	All-cause mortality;Cardiovascular disease;Insulin persistence
Date:	2021
Issue Date:	2022-08-09T08:08:24Z (UTC)
Publisher:	WILEY
ISSN:	2040-1116
Abstract:	Aims/Introduction Studies assessing the long-term outcomes of insulin persistence are scant. We compared the risk of all-cause mortality among patients with different degrees of insulin persistence. Materials and Methods In total, 293,210 patients with type 2 diabetes mellitus undergoing insulin therapy were enrolled during 2002-2014. Insulin persistence was defined as continual insulin treatment without a 90-day gap of discontinuation in the 2-year observation period. Mortality rates were compared between 111,220 patients with >= 90% insulin persistence and 111,220 matched patients with During the mean 5.37-year follow-up period, the mortality rates were 58.26 and 73.21 per 1,000 person-years for patients with >= 90% and <90% of insulin persistence. The adjusted hazard ratio for mortality was 0.80 (95% confidence interval 0.79-0.81,P < 0.001). Patients with high insulin persistence had significantly lower risks than did those with low insulin persistence of death due to hypertension, diabetes, cardiovascular disease, liver disease, kidney disease, respiratory disease, sepsis and cancer. Conclusions This study showed that patients with >= 90% insulin persistence were associated with lower risks of all-cause mortality than did patients with <90% insulin persistence.
URI:	http://dx.doi.org/10.1111/jdi.13330 https://www.webofscience.com/wos/woscc/full-record/WOS:000552147700001 https://ir.csmu.edu.tw:8080/handle/310902500/24813
Relation:	JOURNAL OF DIABETES INVESTIGATION ,2021 ,v12 ,issue 2 ,p146-154
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	167	View/Open

Loading...